Prostacyclin analogues: the next drug-eluting stent?

C. McCormick, R. M. Wadsworth, R. L. Jones, S. Kennedy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent concern over existing drug-eluting stents, for the treatment of myocardial ischaemia, has led to the development of approaches that seek to inhibit restenosis while promoting the recovery of a functional endothelium. Prostacyclin analogues may be worthy candidates for use within a drug-eluting stent by virtue of their wide profile of vasoprotective effects. This article reviews recent developments in this area, and in so doing, reveals the future challenges for the further development of this technology.

Original languageEnglish
Pages (from-to)910-911
Number of pages2
JournalBiochemical Society Transactions
Volume35
Issue numberPart 5
DOIs
Publication statusPublished - Nov 2007
EventFocus Topic at Life Sciences 2007 Conference - Glasgow, United Kingdom
Duration: 9 Jul 200712 Jul 2007

Keywords

  • drug-eluting stent
  • human coronary artery
  • prostacyclin
  • prostanoid receptor
  • restenosis
  • smooth muscle cell proliferation
  • neointima formation
  • coronary-arteries
  • coated stents
  • iloprost
  • pib
  • proliferation
  • receptors
  • cells

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