Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca

Kate Griffiths, Rong Hou, Hairui Wang, Zhihe Zhang, Liang Zhang, Tong Zhang, David G. Watson, Richard J. S. Burchmore, I. Kati Loeffler, Malcolm W. Kennedy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection. Comparison of bear milks with milks of other eutherians yielded distinctive protein profiles. Proteomic and metabolomic analysis of serial milk samples collected from six giant pandas showed a prolonged transition from colostrum to main-phase lactation over approximately 30 days. Particularly striking are the persistence or sequential appearance of adaptive and innate immune factors. The endurance of immunoglobulin G suggests an unusual duration of trans-intestinal absorption of maternal antibodies, and is potentially relevant to the underdeveloped lymphoid system of giant panda neonates. Levels of certain milk oligosaccharides known to exert anti-microbial activities and/or that are conducive to the development of neonatal gut microbiomes underwent an almost complete changeover around days 20-30 postpartum, coincident with the maturation of the protein profile. A potential metabolic marker of starvation was detected, the prominence of which may reflect the natural postpartum period of anorexia in giant panda mothers. Early lactation in giant pandas, and possibly in other ursids, appears to be adapted for the unique requirements of unusually altricial eutherian neonates.

LanguageEnglish
Pages150395
Number of pages14
JournalRoyal Society Open Science
Volume2
Issue number10
DOIs
Publication statusPublished - 21 Oct 2015

Fingerprint

Ursidae
Colostrum
Milk
Lactation
Postpartum Period
Metabolomics
Intestinal Absorption
Immunologic Factors
Anorexia
Starvation
Oligosaccharides
Proteomics
Mammals
Proteins
Immunoglobulin G
Mothers
Antibodies

Keywords

  • giant panda
  • Ailuropoda melanoleuca
  • milk
  • colostrum
  • proteins
  • oligosaccharides

Cite this

Griffiths, Kate ; Hou, Rong ; Wang, Hairui ; Zhang, Zhihe ; Zhang, Liang ; Zhang, Tong ; Watson, David G. ; Burchmore, Richard J. S. ; Loeffler, I. Kati ; Kennedy, Malcolm W. / Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca. In: Royal Society Open Science. 2015 ; Vol. 2, No. 10. pp. 150395.
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Griffiths, K, Hou, R, Wang, H, Zhang, Z, Zhang, L, Zhang, T, Watson, DG, Burchmore, RJS, Loeffler, IK & Kennedy, MW 2015, 'Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca' Royal Society Open Science, vol. 2, no. 10, pp. 150395. https://doi.org/10.1098/rsos.150395

Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca. / Griffiths, Kate; Hou, Rong; Wang, Hairui; Zhang, Zhihe; Zhang, Liang; Zhang, Tong; Watson, David G.; Burchmore, Richard J. S.; Loeffler, I. Kati; Kennedy, Malcolm W.

In: Royal Society Open Science, Vol. 2, No. 10, 21.10.2015, p. 150395.

Research output: Contribution to journalArticle

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