@article{a800b996b87f47129c9b57ace8ed66de,
title = "Profile of a highly selective quaternized pyrrolidine betaine αvβ6 integrin inhibitor - (3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate synthesized by stereoselective methylation",
abstract = "A quaternary ammonium betaine 7 is described which shows exceptional potency and selectivity (1.4 to >3 logs) for the α vβ 6 integrin receptor over the other α v integrins as determined in cell adhesion assays. 7 is prepared by remarkably stereoselective methylation, the origins of which are discussed. The chemical, biological, physicochemical, and pharmacokinetic properties of 7 and its docking into α vβ 6 are described along with related analogues.",
keywords = "idiopathic pulmonary fibrosis, stereoselective methylation, ammonium betaine 7",
author = "Barrett, {Tim N.} and Taylor, {Jonathan A.} and Daniel Barker and Procopiou, {Panayiotis A.} and Thompson, {James D. F.} and John Barrett and Joelle Le and Lynn, {Sean M.} and Peter Pogany and Cassie Pratley and Pritchard, {John M.} and Roper, {James A.} and Rowedder, {James E.} and Slack, {Robert J.} and Giovanni Vitulli and Macdonald, {Simon J. F.} and Kerr, {William J.}",
year = "2019",
month = aug,
day = "22",
doi = "10.1021/acs.jmedchem.9b00819",
language = "English",
volume = "62",
pages = "7543--7556",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "16",
}