Principles of retinal drug delivery from within the vitreous

Clive Wilson, Lay Ean Tan, Jenifer Mains

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In recent years, vitreous humour, a connective tissue at the centre of the eye, emerged as a preferred reservoir for back of the eye drug delivery. Although vitreous humour is largely composed of water (>99%), its physical form can range from a firm gel in the youth to a collapsed gel in the elderly. These changes in the physical form of the vitreous, in conjunction with changes in its composition and turnover, can potentially influence drug delivery to target tissues from the vitreous. In order to enable the reader with the development of personalised medicines for the back of the eye, this chapter discusses vitreal anatomy, convective flow patterns, barriers to drug delivery, drug clearance mechanisms, and the influence of vitrectomy and vitreous substitutes on drug delivery. Further, it presents case studies on interactions of drug delivery systems with vitreous gel as well as the influence of eye movements on drug delivery from the vitreous. Wherever feasible, the above parameters were compared between normal and ageing eyes.
Original languageEnglish
Title of host publicationDrug Product Development for the Back of the Eye
PublisherSpringer
Pages125-158
Number of pages34
DOIs
Publication statusPublished - 2011

Publication series

NameAAPS Advances in the Pharmaceutical Sciences Series
PublisherSpringerLink

Fingerprint

Pharmaceutical Preparations
Vitreous Body
Gels
Precision Medicine
Vitrectomy
Drug Delivery Systems
Eye Movements
Connective Tissue
Anatomy
Water

Keywords

  • retina
  • retinal drug delivery
  • vitreous humour

Cite this

Wilson, C., Tan, L. E., & Mains, J. (2011). Principles of retinal drug delivery from within the vitreous. In Drug Product Development for the Back of the Eye (pp. 125-158). (AAPS Advances in the Pharmaceutical Sciences Series). Springer. https://doi.org/10.1007/978-1-4419-9920-7_6
Wilson, Clive ; Tan, Lay Ean ; Mains, Jenifer. / Principles of retinal drug delivery from within the vitreous. Drug Product Development for the Back of the Eye. Springer, 2011. pp. 125-158 (AAPS Advances in the Pharmaceutical Sciences Series).
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Wilson, C, Tan, LE & Mains, J 2011, Principles of retinal drug delivery from within the vitreous. in Drug Product Development for the Back of the Eye. AAPS Advances in the Pharmaceutical Sciences Series, Springer, pp. 125-158. https://doi.org/10.1007/978-1-4419-9920-7_6

Principles of retinal drug delivery from within the vitreous. / Wilson, Clive; Tan, Lay Ean ; Mains, Jenifer.

Drug Product Development for the Back of the Eye. Springer, 2011. p. 125-158 (AAPS Advances in the Pharmaceutical Sciences Series).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - In recent years, vitreous humour, a connective tissue at the centre of the eye, emerged as a preferred reservoir for back of the eye drug delivery. Although vitreous humour is largely composed of water (>99%), its physical form can range from a firm gel in the youth to a collapsed gel in the elderly. These changes in the physical form of the vitreous, in conjunction with changes in its composition and turnover, can potentially influence drug delivery to target tissues from the vitreous. In order to enable the reader with the development of personalised medicines for the back of the eye, this chapter discusses vitreal anatomy, convective flow patterns, barriers to drug delivery, drug clearance mechanisms, and the influence of vitrectomy and vitreous substitutes on drug delivery. Further, it presents case studies on interactions of drug delivery systems with vitreous gel as well as the influence of eye movements on drug delivery from the vitreous. Wherever feasible, the above parameters were compared between normal and ageing eyes.

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Wilson C, Tan LE, Mains J. Principles of retinal drug delivery from within the vitreous. In Drug Product Development for the Back of the Eye. Springer. 2011. p. 125-158. (AAPS Advances in the Pharmaceutical Sciences Series). https://doi.org/10.1007/978-1-4419-9920-7_6