TY - JOUR
T1 - Principal components analysis of Raman spectra to aid the diagnosis of alzheimer's disease
AU - Archer, J.K.J.
AU - Black, R.A.
AU - Thalmann, D.
AU - Sudworth, C.D.
N1 - Joint BMLA and Lasercare Meeting 2005
PY - 2005
Y1 - 2005
N2 - Abstract of paper from the Joint BMLA and Lasercare Meeting 2005. In the UK 800,000 people suffer from Alzheimer's disease, a figure that is expected to double before 2050. Unlike other dementias, Alzheimer's is not simply an effect
of ageing, but a disease that accounts for 65% of existing
dementias suffered. Currently there is no diagnostic test for Alzheimer's disease. Patients showing symptoms must undergo rigorous physical, psychiatric and neurological examinations (upon which experienced clinicians can only be 90% positive) before diagnosis is attempted; conclusive proof only ensues at post-mortem. The presence of two structural markers, senile plaques and neurofibrillary tangles, are identified at this stage. The disease causes the break down of β-amyloid and tau proteins, destroying neurons. The remaining protein fragments form clumps observed as plaques and tangles.
AB - Abstract of paper from the Joint BMLA and Lasercare Meeting 2005. In the UK 800,000 people suffer from Alzheimer's disease, a figure that is expected to double before 2050. Unlike other dementias, Alzheimer's is not simply an effect
of ageing, but a disease that accounts for 65% of existing
dementias suffered. Currently there is no diagnostic test for Alzheimer's disease. Patients showing symptoms must undergo rigorous physical, psychiatric and neurological examinations (upon which experienced clinicians can only be 90% positive) before diagnosis is attempted; conclusive proof only ensues at post-mortem. The presence of two structural markers, senile plaques and neurofibrillary tangles, are identified at this stage. The disease causes the break down of β-amyloid and tau proteins, destroying neurons. The remaining protein fragments form clumps observed as plaques and tangles.
KW - alzheimer's disease
KW - raman spectra
KW - bioengineering
KW - dementia
UR - http://dx.doi.org/10.1007/s010103-005-0358-6
U2 - 10.1007/s010103-005-0358-6
DO - 10.1007/s010103-005-0358-6
M3 - Article
SN - 0268-8921
VL - 20
SP - B10-B11
JO - Lasers in Medical Science
JF - Lasers in Medical Science
ER -