Presynaptic modulation of dopamine-induced locomotor activity by oxotremorine in nucleus accumbens of the rat

J. S. de Belleroche, P. Winn, E. Murzi, S. F. Williams, L. J. Herberg

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Abstract

Behavioural studies were carried out to determine whether central cholinergic mechanisms regulate dopaminergic activity by presynaptic mechanisms as suggested by recent in vitro studies. Bilateral injections of a muscarinic receptor agonist, oxotremorine (4 μg), into the nucleus accumbens were found to enhance dopamine-induced locomotor activity. In rats deprived of presynaptic terminals by pretreatment with intraaccumbens injections of 6-hydroxydopamine, oxotremorine did not enhance dopamine-induced locomotor activity but on the contrary produced a marked reduction of locomotor activity. Although dopamine induced locomotor activity could occur in 6-hydroxydopamine treated animals, the muscarinic regulation was dependent on the presence of the intact dopamine terminal and hence a presynaptic receptor may be involved.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalJournal of Neural Transmission
Volume54
Issue number3-4
DOIs
Publication statusPublished - 1 Jan 1982

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Keywords

  • 6-hydroxydopamine
  • dopamine-induced locomotor activity
  • nucleus accumbens
  • oxotremorine
  • presynaptic receptors
  • dopamine
  • nialamide
  • animal experiment
  • central nervous system
  • cholinergic system
  • controlled study

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