Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate

R. Couston, E. McBride, C.G. Wilson

Research output: Contribution to journalConference Contribution

Abstract

A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.
LanguageEnglish
PagesA22-A23
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume61
Issue numberS1
DOIs
Publication statusPublished - 2009

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Drug Delivery Systems
Microspheres
Equipment and Supplies
Eye Diseases
Melanins
Macular Degeneration
Incidence
Pharmaceutical Preparations
Brimonidine Tartrate
Therapeutics

Keywords

  • polymeric microspheres
  • ophthalmic drug delivery system
  • brimonidine tartrate

Cite this

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abstract = "A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.",
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Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate. / Couston, R.; McBride, E.; Wilson, C.G.

In: Journal of Pharmacy and Pharmacology, Vol. 61, No. S1, 2009, p. A22-A23.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - Preparation of polymeric microspheres as an ophthalmic drug delivery system for brimonidine tartrate

AU - Couston, R.

AU - McBride, E.

AU - Wilson, C.G.

PY - 2009

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N2 - A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.

AB - A dramatic increase in the incidence of eye diseases, such as age-related macular degeneration, and inadequate therapeutic control has led to the search for advanced methods of sustained and targeted drug delivery. The development of polymeric devices, matrix implants and microspheres has facilitated the prolonged controlled release of therapies to the target sites. The aim of this study is to prepare brimonidine tartrate-loaded microspheres, which possess suitable characteristics for development into an implantable device that will later exploit the binding properties of ocular melanin to influence the release properties.

KW - polymeric microspheres

KW - ophthalmic drug delivery system

KW - brimonidine tartrate

U2 - 10.1211/002235709789037071

DO - 10.1211/002235709789037071

M3 - Conference Contribution

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SP - A22-A23

JO - Journal of Pharmacy and Pharmacology

T2 - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

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