Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds

David M. Lindsay; Wolfgang Dohle; Anne Eeg Jensen; Felix Kopp; Paul  Knochel

doi:10.1021/ol025597x

Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds

David M. Lindsay, Wolfgang Dohle, Anne Eeg Jensen, Felix Kopp, Paul Knochel

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine−magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.

Original language	English
Pages (from-to)	1819-1822
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	11
DOIs	https://doi.org/10.1021/ol025597x
Publication status	Published - 30 Apr 2002

Keywords

functionalization
indoles
reagents
anions
heterocyclic compounds

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10.1021/ol025597x

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@article{96e59439f4c040b98bab3b49cf4e83b4,

title = "Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds",

abstract = "Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine−magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.",

keywords = "functionalization, indoles, reagents, anions, heterocyclic compounds",

author = "Lindsay, \{David M.\} and Wolfgang Dohle and Jensen, \{Anne Eeg\} and Felix Kopp and Paul Knochel",

year = "2002",

month = apr,

day = "30",

doi = "10.1021/ol025597x",

language = "English",

volume = "4",

pages = "1819--1822",

journal = "Organic Letters",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds

AU - Lindsay, David M.

AU - Dohle, Wolfgang

AU - Jensen, Anne Eeg

AU - Kopp, Felix

AU - Knochel, Paul

PY - 2002/4/30

Y1 - 2002/4/30

N2 - Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine−magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.

AB - Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine−magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.

KW - functionalization

KW - indoles

KW - reagents

KW - anions

KW - heterocyclic compounds

U2 - 10.1021/ol025597x

DO - 10.1021/ol025597x

M3 - Article

SN - 1523-7060

VL - 4

SP - 1819

EP - 1822

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds

Abstract

Keywords

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