Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Sriharsha Gupta Potta, Sriharsha Minemi, Ravi Kumar Nukala, Chairmane Peinado, Dimitrios A. Lamprou, Andrew Urquhart, D. Douroumis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.</.

LanguageEnglish
Pages74-81
Number of pages8
JournalJournal of Microencapsulation
Volume28
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Ibuprofen
Nanoparticles
Solubility
Lipids
lipids
solubility
nanoparticles
preparation
Stearic acid
Caco-2 Cells
Differential Scanning Calorimetry
Cytotoxicity
matrices
homogenizing
cells
Particle Size
X-Ray Diffraction
Powders
Differential scanning calorimetry
dissolving

Keywords

  • Ibuprofen
  • solid lipid nanoparticles
  • high-pressure homogenization
  • cytotoxicity
  • controlled drug delivery
  • release
  • system
  • SLN
  • TIC - Bionanotechnology

Cite this

Potta, S. G., Minemi, S., Nukala, R. K., Peinado, C., Lamprou, D. A., Urquhart, A., & Douroumis, D. (2011). Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation , 28(1), 74-81. https://doi.org/10.3109/02652048.2010.529948
Potta, Sriharsha Gupta ; Minemi, Sriharsha ; Nukala, Ravi Kumar ; Peinado, Chairmane ; Lamprou, Dimitrios A. ; Urquhart, Andrew ; Douroumis, D. / Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. In: Journal of Microencapsulation . 2011 ; Vol. 28, No. 1. pp. 74-81.
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Potta, SG, Minemi, S, Nukala, RK, Peinado, C, Lamprou, DA, Urquhart, A & Douroumis, D 2011, 'Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility' Journal of Microencapsulation , vol. 28, no. 1, pp. 74-81. https://doi.org/10.3109/02652048.2010.529948

Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. / Potta, Sriharsha Gupta; Minemi, Sriharsha; Nukala, Ravi Kumar; Peinado, Chairmane; Lamprou, Dimitrios A.; Urquhart, Andrew; Douroumis, D.

In: Journal of Microencapsulation , Vol. 28, No. 1, 2011, p. 74-81.

Research output: Contribution to journalArticle

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