Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Sriharsha Gupta Potta, Sriharsha Minemi, Ravi Kumar Nukala, Chairmane Peinado, Dimitrios A. Lamprou, Andrew Urquhart, D. Douroumis

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Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.</.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Microencapsulation
Volume28
Issue number1
DOIs
Publication statusPublished - 2011

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Keywords

  • Ibuprofen
  • solid lipid nanoparticles
  • high-pressure homogenization
  • cytotoxicity
  • controlled drug delivery
  • release
  • system
  • SLN
  • TIC - Bionanotechnology

Cite this

Potta, S. G., Minemi, S., Nukala, R. K., Peinado, C., Lamprou, D. A., Urquhart, A., & Douroumis, D. (2011). Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. Journal of Microencapsulation , 28(1), 74-81. https://doi.org/10.3109/02652048.2010.529948