Predictors of upper limb recovery after stroke: a systematic review and meta analysis

Fiona Coupar, A.S. Pollock, Philip Rowe, C. Weir, Peter Langhorne

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Aims to systematically review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke. To identify which, if any variables predict upper limb recovery following stroke. We completed searches in MEDLINE, EMBASE, AMED, CINAHL and Cochrane CENTRAL databases. Searches were completed in November 2010. Studies were included if predictor variables were measured at baseline and linked to an outcome of upper limb recovery at a future time point. Exclusion criteria included predictor variables relating to response to treatment and outcome measurements of very specific upper limb impairments such as spasticity or pain. Two independent reviewers completed data extraction and assessed study quality.Fifty-eight studies met the inclusion criteria. Predictor variables which have been considered within these studies include; age, sex, lesion site, initial motor impairment, motor-evoked potentials andsomatosensory-evoked potentials. Initial measures of upper limb impairment and function were found to be the most significant predictors of upper limb recovery; odds ratio 14.84 (95% confidence intervals (CI) 9.08-24.25) and 38.62 (95% CI 8.40-177.53), respectively. Interpretation of these results is complicated by methodological factors including variations in study populations, upper limb motor outcome scales, timing of baseline and outcome assessments and predictors selected. The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function.
LanguageEnglish
Pages291-313
Number of pages23
JournalClinical Rehabilitation
Volume26
Issue number4
Early online date24 Oct 2011
DOIs
Publication statusPublished - 1 May 2012

Fingerprint

Upper Extremity
Meta-Analysis
Stroke
Recovery
Bioelectric potentials
Confidence Intervals
Motor Evoked Potentials
Evoked Potentials
MEDLINE
Odds Ratio
Outcome Assessment (Health Care)
Databases
Pain
Population

Keywords

  • arm
  • rehabilitation
  • predictors
  • upper limb
  • review
  • stroke
  • meta analysis

Cite this

Coupar, Fiona ; Pollock, A.S. ; Rowe, Philip ; Weir, C. ; Langhorne, Peter. / Predictors of upper limb recovery after stroke : a systematic review and meta analysis. In: Clinical Rehabilitation. 2012 ; Vol. 26, No. 4. pp. 291-313.
@article{d1aab5fcd9c748bbbe4a24c4f904df54,
title = "Predictors of upper limb recovery after stroke: a systematic review and meta analysis",
abstract = "Aims to systematically review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke. To identify which, if any variables predict upper limb recovery following stroke. We completed searches in MEDLINE, EMBASE, AMED, CINAHL and Cochrane CENTRAL databases. Searches were completed in November 2010. Studies were included if predictor variables were measured at baseline and linked to an outcome of upper limb recovery at a future time point. Exclusion criteria included predictor variables relating to response to treatment and outcome measurements of very specific upper limb impairments such as spasticity or pain. Two independent reviewers completed data extraction and assessed study quality.Fifty-eight studies met the inclusion criteria. Predictor variables which have been considered within these studies include; age, sex, lesion site, initial motor impairment, motor-evoked potentials andsomatosensory-evoked potentials. Initial measures of upper limb impairment and function were found to be the most significant predictors of upper limb recovery; odds ratio 14.84 (95{\%} confidence intervals (CI) 9.08-24.25) and 38.62 (95{\%} CI 8.40-177.53), respectively. Interpretation of these results is complicated by methodological factors including variations in study populations, upper limb motor outcome scales, timing of baseline and outcome assessments and predictors selected. The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function.",
keywords = "arm , rehabilitation, predictors , upper limb, review, stroke, meta analysis",
author = "Fiona Coupar and A.S. Pollock and Philip Rowe and C. Weir and Peter Langhorne",
year = "2012",
month = "5",
day = "1",
doi = "10.1177/0269215511420305",
language = "English",
volume = "26",
pages = "291--313",
journal = "Clinical Rehabilitation",
issn = "0269-2155",
number = "4",

}

Predictors of upper limb recovery after stroke : a systematic review and meta analysis. / Coupar, Fiona; Pollock, A.S.; Rowe, Philip; Weir, C.; Langhorne, Peter.

In: Clinical Rehabilitation, Vol. 26, No. 4, 01.05.2012, p. 291-313.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictors of upper limb recovery after stroke

T2 - Clinical Rehabilitation

AU - Coupar, Fiona

AU - Pollock, A.S.

AU - Rowe, Philip

AU - Weir, C.

AU - Langhorne, Peter

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Aims to systematically review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke. To identify which, if any variables predict upper limb recovery following stroke. We completed searches in MEDLINE, EMBASE, AMED, CINAHL and Cochrane CENTRAL databases. Searches were completed in November 2010. Studies were included if predictor variables were measured at baseline and linked to an outcome of upper limb recovery at a future time point. Exclusion criteria included predictor variables relating to response to treatment and outcome measurements of very specific upper limb impairments such as spasticity or pain. Two independent reviewers completed data extraction and assessed study quality.Fifty-eight studies met the inclusion criteria. Predictor variables which have been considered within these studies include; age, sex, lesion site, initial motor impairment, motor-evoked potentials andsomatosensory-evoked potentials. Initial measures of upper limb impairment and function were found to be the most significant predictors of upper limb recovery; odds ratio 14.84 (95% confidence intervals (CI) 9.08-24.25) and 38.62 (95% CI 8.40-177.53), respectively. Interpretation of these results is complicated by methodological factors including variations in study populations, upper limb motor outcome scales, timing of baseline and outcome assessments and predictors selected. The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function.

AB - Aims to systematically review and summarize the current available literature on prognostic variables relating to upper limb recovery following stroke. To identify which, if any variables predict upper limb recovery following stroke. We completed searches in MEDLINE, EMBASE, AMED, CINAHL and Cochrane CENTRAL databases. Searches were completed in November 2010. Studies were included if predictor variables were measured at baseline and linked to an outcome of upper limb recovery at a future time point. Exclusion criteria included predictor variables relating to response to treatment and outcome measurements of very specific upper limb impairments such as spasticity or pain. Two independent reviewers completed data extraction and assessed study quality.Fifty-eight studies met the inclusion criteria. Predictor variables which have been considered within these studies include; age, sex, lesion site, initial motor impairment, motor-evoked potentials andsomatosensory-evoked potentials. Initial measures of upper limb impairment and function were found to be the most significant predictors of upper limb recovery; odds ratio 14.84 (95% confidence intervals (CI) 9.08-24.25) and 38.62 (95% CI 8.40-177.53), respectively. Interpretation of these results is complicated by methodological factors including variations in study populations, upper limb motor outcome scales, timing of baseline and outcome assessments and predictors selected. The most important predictive factors for upper limb recovery following stroke appears to the initial severity of motor impairment or function.

KW - arm

KW - rehabilitation

KW - predictors

KW - upper limb

KW - review

KW - stroke

KW - meta analysis

UR - http://www.scopus.com/inward/record.url?scp=84858010643&partnerID=8YFLogxK

U2 - 10.1177/0269215511420305

DO - 10.1177/0269215511420305

M3 - Article

VL - 26

SP - 291

EP - 313

JO - Clinical Rehabilitation

JF - Clinical Rehabilitation

SN - 0269-2155

IS - 4

ER -