Predictors of tuberculosis treatment success under the DOTS program in Namibia

Dan Kibuule, Roger K Verbeeck, Ruswa Nunurai, Farai Mavungha, Ette Ene, Brian Godman, Timothy W Rennie

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Optimal treatment success rates are critical to end tuberculosis in Namibia. Despite the scale-up of high quality DOTS in Namibia, treatment success falls short of the global target of 90%. Consequently, the objective of this study was to ascertain the predictors of treatment success rates under DOTS in Namibia to provide future direction. Methods: A nation-wide comparative analysis of predictors of treatment success was undertaken. Tuberculosis cases in the electronic tuberculosis register were retrospectively reviewed over a 10-year period, 2004-2016. The patient, programmatic, clinical and treatment predictors of treatment success were determined by multivariate logistic regression modeling using R software. Results: 104,603 TB cases were registered at 300 DOTS sites in 37 districts. The 10-year period treatment success rate was 80%, and varied by region (77.2%-89.2%). The patient’s sex and age were not significant predictors of treatment success. The independent predictors for treatment success as were: Region of DOTS implementation (p=0.001), type of DOT supporter (p<0.001), sputum conversion at 2 months (p=0.013), DOT regimen (p<0.001), cotrimoxazole prophylaxis (p=0.002) and HIV co-infection (p=0.001). Conclusion: Targeted programmatic, clinical and treatment interventions are required to enhance DOTS treatment success in Namibia. These are now ongoing.
LanguageEnglish
Pages979-987
Number of pages9
JournalExpert Review of Respiratory Medicine
Volume12
Issue number11
Early online date4 Oct 2018
DOIs
Publication statusPublished - 30 Nov 2018

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Namibia
Tuberculosis
Therapeutics
Sulfamethoxazole Drug Combination Trimethoprim
Sputum
Coinfection
HIV Infections

Keywords

  • DOTS program
  • TB
  • tuberculosis
  • effectiveness

Cite this

Kibuule, Dan ; Verbeeck, Roger K ; Nunurai, Ruswa ; Mavungha, Farai ; Ene, Ette ; Godman, Brian ; Rennie, Timothy W. / Predictors of tuberculosis treatment success under the DOTS program in Namibia. In: Expert Review of Respiratory Medicine. 2018 ; Vol. 12, No. 11. pp. 979-987.
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Predictors of tuberculosis treatment success under the DOTS program in Namibia. / Kibuule, Dan; Verbeeck, Roger K; Nunurai, Ruswa; Mavungha, Farai; Ene, Ette; Godman, Brian; Rennie, Timothy W.

In: Expert Review of Respiratory Medicine, Vol. 12, No. 11, 30.11.2018, p. 979-987.

Research output: Contribution to journalArticle

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