Abstract
| Language | English |
|---|---|
| Pages | 979-987 |
| Number of pages | 9 |
| Journal | Expert Review of Respiratory Medicine |
| Volume | 12 |
| Issue number | 11 |
| Early online date | 4 Oct 2018 |
| DOIs | |
| Publication status | Published - 30 Nov 2018 |
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Keywords
- DOTS program
- TB
- tuberculosis
- effectiveness
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Predictors of tuberculosis treatment success under the DOTS program in Namibia. / Kibuule, Dan; Verbeeck, Roger K; Nunurai, Ruswa; Mavungha, Farai; Ene, Ette; Godman, Brian; Rennie, Timothy W.
In: Expert Review of Respiratory Medicine, Vol. 12, No. 11, 30.11.2018, p. 979-987.Research output: Contribution to journal › Article
TY - JOUR
T1 - Predictors of tuberculosis treatment success under the DOTS program in Namibia
AU - Kibuule, Dan
AU - Verbeeck, Roger K
AU - Nunurai, Ruswa
AU - Mavungha, Farai
AU - Ene, Ette
AU - Godman, Brian
AU - Rennie, Timothy W
PY - 2018/11/30
Y1 - 2018/11/30
N2 - Objectives: Optimal treatment success rates are critical to end tuberculosis in Namibia. Despite the scale-up of high quality DOTS in Namibia, treatment success falls short of the global target of 90%. Consequently, the objective of this study was to ascertain the predictors of treatment success rates under DOTS in Namibia to provide future direction. Methods: A nation-wide comparative analysis of predictors of treatment success was undertaken. Tuberculosis cases in the electronic tuberculosis register were retrospectively reviewed over a 10-year period, 2004-2016. The patient, programmatic, clinical and treatment predictors of treatment success were determined by multivariate logistic regression modeling using R software. Results: 104,603 TB cases were registered at 300 DOTS sites in 37 districts. The 10-year period treatment success rate was 80%, and varied by region (77.2%-89.2%). The patient’s sex and age were not significant predictors of treatment success. The independent predictors for treatment success as were: Region of DOTS implementation (p=0.001), type of DOT supporter (p<0.001), sputum conversion at 2 months (p=0.013), DOT regimen (p<0.001), cotrimoxazole prophylaxis (p=0.002) and HIV co-infection (p=0.001). Conclusion: Targeted programmatic, clinical and treatment interventions are required to enhance DOTS treatment success in Namibia. These are now ongoing.
AB - Objectives: Optimal treatment success rates are critical to end tuberculosis in Namibia. Despite the scale-up of high quality DOTS in Namibia, treatment success falls short of the global target of 90%. Consequently, the objective of this study was to ascertain the predictors of treatment success rates under DOTS in Namibia to provide future direction. Methods: A nation-wide comparative analysis of predictors of treatment success was undertaken. Tuberculosis cases in the electronic tuberculosis register were retrospectively reviewed over a 10-year period, 2004-2016. The patient, programmatic, clinical and treatment predictors of treatment success were determined by multivariate logistic regression modeling using R software. Results: 104,603 TB cases were registered at 300 DOTS sites in 37 districts. The 10-year period treatment success rate was 80%, and varied by region (77.2%-89.2%). The patient’s sex and age were not significant predictors of treatment success. The independent predictors for treatment success as were: Region of DOTS implementation (p=0.001), type of DOT supporter (p<0.001), sputum conversion at 2 months (p=0.013), DOT regimen (p<0.001), cotrimoxazole prophylaxis (p=0.002) and HIV co-infection (p=0.001). Conclusion: Targeted programmatic, clinical and treatment interventions are required to enhance DOTS treatment success in Namibia. These are now ongoing.
KW - DOTS program
KW - TB
KW - tuberculosis
KW - effectiveness
U2 - 10.1080/17476348.2018.1520637
DO - 10.1080/17476348.2018.1520637
M3 - Article
VL - 12
SP - 979
EP - 987
JO - Expert Review of Respiratory Medicine
T2 - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 11
ER -