Abstract
| Language | English |
|---|---|
| Pages | 2370-2374 |
| Number of pages | 5 |
| Journal | Angewandte Chemie |
| Volume | 45 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2006 |
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Keywords
- alkali metals
- amides
- complex-induced proximity effect
- metalation
- zinc
- lithiation
Cite this
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Pre-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide. / Clegg, W ; Dale, S H ; Hevia, E ; Honeyman, G W ; Mulvey, R E .
In: Angewandte Chemie, Vol. 45, No. 15, 2006, p. 2370-2374.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pre-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide
AU - Clegg, W
AU - Dale, S H
AU - Hevia, E
AU - Honeyman, G W
AU - Mulvey, R E
PY - 2006
Y1 - 2006
N2 - The predator meets its prey in the structure of [{(iPr)2NC(Ph)(O)}Li(μ-tmp)(μ-tBu)Zn(tBu)] which reveals an aromatic amide–alkali metal zincate “precomplex” for directed ortho-metalation (DoM) that exists prior to the devouring (ortho-zincation) of the amide by the zincate. tmp=2,2,6,6-tetramethylpiperidide.
AB - The predator meets its prey in the structure of [{(iPr)2NC(Ph)(O)}Li(μ-tmp)(μ-tBu)Zn(tBu)] which reveals an aromatic amide–alkali metal zincate “precomplex” for directed ortho-metalation (DoM) that exists prior to the devouring (ortho-zincation) of the amide by the zincate. tmp=2,2,6,6-tetramethylpiperidide.
KW - alkali metals
KW - amides
KW - complex-induced proximity effect
KW - metalation
KW - zinc
KW - lithiation
U2 - 10.1002/anie.200503202
DO - 10.1002/anie.200503202
M3 - Article
VL - 45
SP - 2370
EP - 2374
JO - Angewandte Chemie International Edition
T2 - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 15
ER -