Pre-clinical bioimaging in a mouse model of rheumatoid arthritis

Michelle Ierna, Karen Smith, Kirsty Ross, Gordon Meiklejohn, Pasquale Maffia, James M. Brewer, Iain B. McInnes, Paul Garside

Research output: Contribution to journalSpecial issue

Abstract

The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.
Original languageEnglish
Pages (from-to)S75-S75
Number of pages1
JournalArthritis and Rheumatism
Volume63
Issue number10
Publication statusPublished - Oct 2011

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Keywords

  • bioimaging
  • rheumatoid arthritis
  • arthritis
  • rheumatism

Cite this

Ierna, M., Smith, K., Ross, K., Meiklejohn, G., Maffia, P., Brewer, J. M., ... Garside, P. (2011). Pre-clinical bioimaging in a mouse model of rheumatoid arthritis. Arthritis and Rheumatism, 63(10), S75-S75.