Pre- and postjunctional blocking effects of aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics

Y N Singh, I G Marshall, A L Harvey

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50 Citations (Scopus)

Abstract

The effects of seven antibiotics (streptomycin, amikacin, polymyxin B, lincomycin, clindamycin, tetracycline and oxytetracycline) were compared with those of magnesium, tubocurarine and lignocaine in the frog sciatic nerve--sartorius muscle preparation, using intracellular recording techniques. All compounds except tubocurarine decreased end-plate potential quantal content. The prejunctional effects of magnesium, streptomycin, amikacin, polymyxin B and oxytetracycline (but not the other drugs) were well reversed by increasing the calcium concentration. At concentrations which depressed quantal content, only magnesium, tetracycline and oxytetracycline did not reduce postjunctional sensitivity. Further postjunctional effects of the drugs were revealed by alterations in the time-courses of end-plate potentials. All the drugs tested except magnesium, tubocurarine and lincomycin produced changes in muscle action potentials. None of the compounds had anticholinesterase activity. The results confirm that aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics produce neuromuscular block by a combination of both pre- and postjunctional actions.
Original languageEnglish
Pages (from-to)1295-1306
Number of pages12
JournalBritish Journal of Anaesthesia
Volume54
Issue number12
DOIs
Publication statusPublished - 1982

Keywords

  • action potentials
  • aminoglycosides
  • animals
  • anti-bacterial agents
  • lincomycin
  • membrane potentials
  • motor endplate
  • neuromuscular junction
  • polymyxin B
  • rana pipiens
  • rana temporaria
  • synaptic transmission
  • tetracyclines

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