Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

Peter S. Campbell; Craig Jamieson; Iain Simpson; Allan J. B. Watson

doi:10.1039/C7CC08670A

Practical synthesis of pharmaceutically relevant molecules enriched in sp³ character

Peter S. Campbell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

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17 Citations (Scopus)

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Abstract

The expedient synthesis of compounds enriched in sp³ character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki-Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

Original language	English
Number of pages	4
Journal	Chemical Communications (London)
Early online date	27 Nov 2017
DOIs	https://doi.org/10.1039/C7CC08670A
Publication status	E-pub ahead of print - 27 Nov 2017

Keywords

synthesis
sp3
drug discovery

Access to Document

10.1039/C7CC08670A

Campbell-etal-CC2017-Practical-synthesis-of-pharmaceutically-relevant-molecules-enrichedAccepted author manuscript, 875 KB

Cite this

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