Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

Peter S. Campbell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

Research output: Contribution to journalArticle

8 Citations (Scopus)
12 Downloads (Pure)

Abstract

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki-Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.
Original languageEnglish
Number of pages4
JournalChemical Communications (London)
Early online date27 Nov 2017
DOIs
Publication statusE-pub ahead of print - 27 Nov 2017

Keywords

  • synthesis
  • sp3
  • drug discovery

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