Potential use of the Diels-Alder reaction in biomedical and nanomedicine applications

Adeolu Oluwasanmi, Clare Hoskins

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)
938 Downloads (Pure)


The Diels-Alder reaction and its retro breakdown has garnered increasing research focus due to several of its advantageous properties including, atomic conservation, reversibility, and substituent retention. This is especially true in biomedical application and nanomedicine development which display a preference for rapid, efficient, and clean “click” chemistry reactions allowing for delivery of active ingredients and subsequent release upon temperature elevation. There are multiple variations on the Diels-Alder based around substitution position and materials being coupled which can affect the temperature threshold for and rate of the retro reaction reversal. Hence, the Diels-Alder offers a simple coupling reaction for active ingredients with tailorable release. In this review the incorporation of the Diels-Alder chemistries and linkers within the biomedical and nanomedicine field will be discussed, as well as its use in future potential technologies.
Original languageEnglish
Article number120727
Number of pages33
JournalInternational Journal of Pharmaceutics
Early online date23 May 2021
Publication statusPublished - 15 Jul 2021


  • Diels-Alder
  • drug delivery
  • intelligent delivery
  • triggered release


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