Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells

Alison Gurney, Oleg Osipenko, Debbi MacMillan, Fiona Kempsill

Research output: Contribution to journalLiterature review

46 Citations (Scopus)

Abstract

1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined. 2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved. 3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential. 4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.

LanguageEnglish
Article number11985545
Pages330-333
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume29
Issue number4
Early online date5 Mar 2002
DOIs
Publication statusPublished - Apr 2002

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Potassium Channels
Membrane Potentials
Pulmonary Artery
Smooth Muscle Myocytes
Membranes
Hypoxia

Keywords

  • hypoxia
  • pulmonary artery
  • smooth muscle
  • vasoconstriction
  • two-pore domain acid-sentitive K channels
  • resting potential
  • pulmonary hypertension
  • membrane potential
  • K channel
  • Kv

Cite this

Gurney, Alison ; Osipenko, Oleg ; MacMillan, Debbi ; Kempsill, Fiona. / Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells. In: Clinical and Experimental Pharmacology and Physiology . 2002 ; Vol. 29, No. 4. pp. 330-333.
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Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells. / Gurney, Alison; Osipenko, Oleg; MacMillan, Debbi; Kempsill, Fiona.

In: Clinical and Experimental Pharmacology and Physiology , Vol. 29, No. 4, 11985545, 04.2002, p. 330-333.

Research output: Contribution to journalLiterature review

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N2 - 1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined. 2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved. 3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential. 4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.

AB - 1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined. 2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved. 3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential. 4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.

KW - hypoxia

KW - pulmonary artery

KW - smooth muscle

KW - vasoconstriction

KW - two-pore domain acid-sentitive K channels

KW - resting potential

KW - pulmonary hypertension

KW - membrane potential

KW - K channel

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