Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells

Alison Gurney, Oleg Osipenko, Debbi MacMillan, Fiona Kempsill

Research output: Contribution to journalLiterature review

46 Citations (Scopus)

Abstract

1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined. 2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved. 3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential. 4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.

Original languageEnglish
Article number11985545
Pages (from-to)330-333
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume29
Issue number4
Early online date5 Mar 2002
DOIs
Publication statusPublished - Apr 2002

Keywords

  • hypoxia
  • pulmonary artery
  • smooth muscle
  • vasoconstriction
  • two-pore domain acid-sentitive K channels
  • resting potential
  • pulmonary hypertension
  • membrane potential
  • K channel
  • Kv

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