Potassium channel toxins and transmitter release

A.L. Harvey, E.G. Rowan, H. Vatanpour, M. Fatehi, O. Castaneda, E. Karlsson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Much has been learned about the physiological functions of ion channels in neuronal membranes from studies on the effects of naturally occurring neurotoxins. Many toxins have been found to act at Na+, K+, or Ca" channels. In this article, toxins acting on K+ channels to facilitate neurotransmission will be reviewed. Toxins affecting neuronal K + channels have attracted considerable interest recently (for reviews, see references 1-3). They include noxiustoxin from the Mexican scorpion Centruroides no~iusa,p~am in5 and mast cell degranulating peptide6 from the honeybee Apis mellifera, the dendrotoxins from mamba (Dendroaspis) snake^,^ and charybdotoxin from the Old World scorpion Leiurus quinquestriatd (TABLE I). These toxins are highly potent blockers of K+ currents in neurons, but they differ in selectivity for subtypes of K+ channels. For example, apamin blocks certain Caz+-activated K+ channels, whereas the dendrotoxins act on a subset of voltage-dependent K+ channels. Some of the toxins act exclusively on neurons (e.g., dendrotoxins), whereas others affect K+ channels in several different cell types. Actions of toxins on voltagedependent K+ channels and on Ca2+-activated K+ channels and their effects on neuromuscular transmission will be described here.
LanguageEnglish
Pages1-10
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume710
DOIs
Publication statusPublished - 1994

Fingerprint

Potassium Channels
Elapidae
Transmitters
Neurons
Apamin
Scorpions
Calcium-Activated Potassium Channels
Snakes
Bees
Neurotoxins
Ion Channels
Mast Cells
Synaptic Transmission
Membranes
Electric potential
dendrotoxin
Cells
Neuron
Membrane

Keywords

  • potassium
  • toxins
  • transmitter release

Cite this

Harvey, A.L. ; Rowan, E.G. ; Vatanpour, H. ; Fatehi, M. ; Castaneda, O. ; Karlsson, E. / Potassium channel toxins and transmitter release. In: Annals of the New York Academy of Sciences. 1994 ; Vol. 710. pp. 1-10.
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Potassium channel toxins and transmitter release. / Harvey, A.L.; Rowan, E.G.; Vatanpour, H.; Fatehi, M.; Castaneda, O.; Karlsson, E.

In: Annals of the New York Academy of Sciences, Vol. 710, 1994, p. 1-10.

Research output: Contribution to journalArticle

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T1 - Potassium channel toxins and transmitter release

AU - Harvey, A.L.

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