Using structurally well-defined dipotassium- tetra(alkyl)magnesiates, a new straightforward methodology to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. Contacted ion pair intermediates are likely to be involved, with K being the key to facilitate the magnesiation processes.
- Mg–H exchange reactions
- heteroaromatic substrates
Baillie, S. E., Bluemke, T. D., Clegg, W., Kennedy, A. R., Klett, J., Russo, L., ... Hevia, E. (2014). Potassium-alkyl magnesiates: synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates. Chemical Communications, 50, 12859-12862. https://doi.org/10.1039/C4CC05305B