Posttranslational modifications of GLUT4 affect its subcellular localization and translocation

Jessica B. A. Sadler, Nia J. Bryant, Gwyn W. Gould, Cassie R. Welburn

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intracellularly by continuous trafficking through two inter-related cycles. GLUT4 passes through recycling endosomes, the trans Golgi network and an insulin-sensitive intracellular compartment, termed GLUT4-storage vesicles or GSVs. It is from GSVs that GLUT4 is mobilized to the cell surface in response to insulin, where it increases the rate of glucose uptake into the cell. As with many physiological responses to external stimuli, this regulated trafficking event involves multiple posttranslational modifications. This review outlines the roles of posttranslational modifications of GLUT4 on its function and insulin-regulated trafficking.

LanguageEnglish
Pages9963-9978
Number of pages16
JournalInternational Journal of Molecular Sciences
Volume14
Issue number5
DOIs
Publication statusPublished - 10 May 2013

Fingerprint

Glucose Transporter Type 4
transporter
Post Translational Protein Processing
glucose
Glucose
insulin
Insulin
trans-Golgi Network
physiological responses
Endosomes
Cell membranes
homeostasis
Organelles
organelles
Muscle
Recycling
compartments
Homeostasis
muscles
recycling

Keywords

  • GLUT4
  • phosphorylation
  • posttranslational modification
  • SUMO
  • transport
  • ubiquitin

Cite this

Sadler, Jessica B. A. ; Bryant, Nia J. ; Gould, Gwyn W. ; Welburn, Cassie R. / Posttranslational modifications of GLUT4 affect its subcellular localization and translocation. In: International Journal of Molecular Sciences. 2013 ; Vol. 14, No. 5. pp. 9963-9978.
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Posttranslational modifications of GLUT4 affect its subcellular localization and translocation. / Sadler, Jessica B. A.; Bryant, Nia J.; Gould, Gwyn W.; Welburn, Cassie R.

In: International Journal of Molecular Sciences, Vol. 14, No. 5, 10.05.2013, p. 9963-9978.

Research output: Contribution to journalReview article

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