Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide

W Clegg, S H Dale, R W Harrington, E Hevia, G W Honeyman, R E Mulvey

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.
Original languageEnglish
Pages (from-to)2374-2377
Number of pages4
JournalAngewandte Chemie
Volume45
Issue number15
DOIs
Publication statusPublished - 2006

Keywords

  • alkali metals
  • amides
  • directing groups
  • metalation
  • zinc
  • zinc exchange-reaction
  • lithiation
  • reagents
  • reactivities
  • alkyl

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