Invisible using standard electrophilic substitution detection methods, two distinct ortho-metalated “intermediates” generated by alkali-metal-mediated zincation of N,N-diisopropylbenzamide are structurally elucidated.
- alkali metals
- directing groups
- zinc exchange-reaction
Clegg, W., Dale, S. H., Harrington, R. W., Hevia, E., Honeyman, G. W., & Mulvey, R. E. (2006). Post-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide. Angewandte Chemie, 45(15), 2374-2377. https://doi.org/10.1002/anie.200503213