Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor

Simon J.A. Grove, Craig Jamieson, John K.F. Maclean, John A. Morrow, Zoran Rankovic

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Abstract

L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate.
Original languageEnglish
Pages (from-to)7271-7279
Number of pages8
JournalJournal of Medicinal Chemistry
Volume53
Issue number20
DOIs
Publication statusPublished - 2010

Keywords

  • allosteric modulators
  • medicinal chemistry
  • neurotransmitter
  • central nervous system

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