Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor

Simon J.A. Grove, Craig Jamieson, John K.F. Maclean, John A. Morrow, Zoran Rankovic

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood. The physiological effects of glutamate are mediated through two functionally distinct receptor families. While activation of metabotropic (G-protein coupled) glutamate receptors results in modulation of neuronal excitability and transmission, the ionotropic glutamate receptors (ligand-gated ion channels) are responsible for mediating the fast synaptic response to extracellular glutamate.
LanguageEnglish
Pages7271-7279
Number of pages8
JournalJournal of Medicinal Chemistry
Volume53
Issue number20
DOIs
Publication statusPublished - 2010

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AMPA Receptors
Glutamic Acid
Acids
Ligand-Gated Ion Channels
Ionotropic Glutamate Receptors
Glutamate Receptors
G-Protein-Coupled Receptors
Cognition
Neurotransmitter Agents
Central Nervous System

Keywords

  • allosteric modulators
  • medicinal chemistry
  • neurotransmitter
  • central nervous system

Cite this

Grove, Simon J.A. ; Jamieson, Craig ; Maclean, John K.F. ; Morrow, John A. ; Rankovic, Zoran. / Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In: Journal of Medicinal Chemistry. 2010 ; Vol. 53, No. 20. pp. 7271-7279.
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Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. / Grove, Simon J.A.; Jamieson, Craig; Maclean, John K.F.; Morrow, John A.; Rankovic, Zoran.

In: Journal of Medicinal Chemistry, Vol. 53, No. 20, 2010, p. 7271-7279.

Research output: Contribution to journalArticle

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