Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications

Hélder A Santos, Ermei Mäkilä, Anu J Airaksinen, Luis M Bimbo, Jouni Hirvonen

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

The research on porous silicon (PSi) materials for biomedical applications has expanded greatly since the early studies of Leigh Canham more than 25 years ago. Currently, PSi nanoparticles are receiving growing attention from the scientific biomedical community. These nanostructured materials have emerged as promising multifunctional and versatile platforms for nanomedicine in drug delivery, diagnostics and therapy. The outstanding properties of PSi, including excellent in vivo biocompatibility and biodegradability, have led to many applications of PSi for delivery of therapeutic agents. In this review, we highlight current advances and recent efforts on PSi nanoparticles regarding the production properties, efficient drug delivery, multidrug delivery, permeation across biological barriers, biosafety and in vivo tracking for biomedical applications. The constant boost on successful preclinical in vivo data reported so far makes this the 'golden age' for PSi, which is expected to finally be translated into the clinic in the near future.

LanguageEnglish
Pages535-554
Number of pages20
JournalNanomedicine
Volume9
Issue number4
DOIs
Publication statusPublished - 31 Mar 2014
Externally publishedYes

Fingerprint

Nanomedicine
Medical nanotechnology
Porous silicon
Silicon
Nanoparticles
Drug delivery
Nanostructures
Biodegradability
Biocompatibility
Nanostructured materials
Permeation
Pharmaceutical Preparations
Therapeutics
Research

Keywords

  • silicon
  • drug delivery systems
  • biomedical applications
  • nanomedicine
  • nanoparticles
  • porosity
  • animal

Cite this

Santos, Hélder A ; Mäkilä, Ermei ; Airaksinen, Anu J ; Bimbo, Luis M ; Hirvonen, Jouni. / Porous silicon nanoparticles for nanomedicine : preparation and biomedical applications. In: Nanomedicine. 2014 ; Vol. 9, No. 4. pp. 535-554.
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Porous silicon nanoparticles for nanomedicine : preparation and biomedical applications. / Santos, Hélder A; Mäkilä, Ermei; Airaksinen, Anu J; Bimbo, Luis M; Hirvonen, Jouni.

In: Nanomedicine, Vol. 9, No. 4, 31.03.2014, p. 535-554.

Research output: Contribution to journalReview article

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