Porous silicon nanoparticles

Hélder A Santos, Ermei Mäkilä, Luis Bimbo, Patrick Almeida, Jouni Hirvonen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Micro- and nano-based technologies are presently recognized as promising potential tools for drug delivery applications in almost every field of health sciences, aiming to overcome the adverse physicochemical properties of conventional drug molecules, which often lead to poor drug bioavailability. A large amount of the new chemical entities developed by the pharmaceutical industry are poorly water-soluble compounds, which in order to subsist as efficient drugs with improved and controllable in vivo behaviour require the aid of more advanced technologies. In this context, porous silicon (PSi) nanocarriers have received considerable attention for the delivery of a wide range of therapeutics, particularly due to their excellent in vivo biocompatibility, easy surface chemical modification and easy control over their porous network structure. The literature has extensively demonstrated the successful use of PSi for controlling the loading and release of poorly water-soluble drugs; however, in this chapter we will mainly focus on the applications of the PSi-based nanoparticles for biomedical applications. In this chapter, we start by addressing the issues of poorly water-soluble drugs and then introduce PSi-based materials as potential drug carriers for such drugs. We then highlight the fabrication methodology of PSi materials, the drug loading and release, and present several examples of the significant potential of PSi in biomedical imaging and in drug delivery applications. These applications exploit these promising features of PSi for future translation to the clinic. We will conclude the chapter with a brief overview of our visions of the future of the PSi nanomaterials and their implications in the pharmaceutical and biomedical field.
LanguageEnglish
Title of host publicationFundamentals of Pharmaceutical Nanoscience
EditorsIjeoma F. Uchegbu, Andreas G. Schätzlein, Woei Ping Cheng, Aikaterini Lalatsa
Place of PublicationNew York
PublisherSpringer Science + Business Media
Pages235–275
Number of pages41
ISBN (Print)9781461491637
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Silicon
Nanoparticles
Pharmaceutical Preparations
Water
Technology
Drug Carriers
Nanostructures
Drug Industry
Biological Availability
Health

Keywords

  • porous silicon
  • nanoparticles
  • drug delivery
  • nanocarriers
  • biomedical applications
  • fabrication procedures

Cite this

Santos, H. A., Mäkilä, E., Bimbo, L., Almeida, P., & Hirvonen, J. (2013). Porous silicon nanoparticles. In I. F. Uchegbu, A. G. Schätzlein, W. Ping Cheng, & A. Lalatsa (Eds.), Fundamentals of Pharmaceutical Nanoscience (pp. 235–275). New York: Springer Science + Business Media. https://doi.org/10.1007%2F978-1-4614-9164-4_10
Santos, Hélder A ; Mäkilä, Ermei ; Bimbo, Luis ; Almeida, Patrick ; Hirvonen, Jouni. / Porous silicon nanoparticles. Fundamentals of Pharmaceutical Nanoscience. editor / Ijeoma F. Uchegbu ; Andreas G. Schätzlein ; Woei Ping Cheng ; Aikaterini Lalatsa. New York : Springer Science + Business Media, 2013. pp. 235–275
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Santos, HA, Mäkilä, E, Bimbo, L, Almeida, P & Hirvonen, J 2013, Porous silicon nanoparticles. in I F. Uchegbu, A G. Schätzlein, W Ping Cheng & A Lalatsa (eds), Fundamentals of Pharmaceutical Nanoscience. Springer Science + Business Media, New York, pp. 235–275. https://doi.org/10.1007%2F978-1-4614-9164-4_10

Porous silicon nanoparticles. / Santos, Hélder A; Mäkilä, Ermei; Bimbo, Luis; Almeida, Patrick; Hirvonen, Jouni.

Fundamentals of Pharmaceutical Nanoscience. ed. / Ijeoma F. Uchegbu; Andreas G. Schätzlein; Woei Ping Cheng; Aikaterini Lalatsa. New York : Springer Science + Business Media, 2013. p. 235–275.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Porous silicon nanoparticles

AU - Santos, Hélder A

AU - Mäkilä, Ermei

AU - Bimbo, Luis

AU - Almeida, Patrick

AU - Hirvonen, Jouni

PY - 2013

Y1 - 2013

N2 - Micro- and nano-based technologies are presently recognized as promising potential tools for drug delivery applications in almost every field of health sciences, aiming to overcome the adverse physicochemical properties of conventional drug molecules, which often lead to poor drug bioavailability. A large amount of the new chemical entities developed by the pharmaceutical industry are poorly water-soluble compounds, which in order to subsist as efficient drugs with improved and controllable in vivo behaviour require the aid of more advanced technologies. In this context, porous silicon (PSi) nanocarriers have received considerable attention for the delivery of a wide range of therapeutics, particularly due to their excellent in vivo biocompatibility, easy surface chemical modification and easy control over their porous network structure. The literature has extensively demonstrated the successful use of PSi for controlling the loading and release of poorly water-soluble drugs; however, in this chapter we will mainly focus on the applications of the PSi-based nanoparticles for biomedical applications. In this chapter, we start by addressing the issues of poorly water-soluble drugs and then introduce PSi-based materials as potential drug carriers for such drugs. We then highlight the fabrication methodology of PSi materials, the drug loading and release, and present several examples of the significant potential of PSi in biomedical imaging and in drug delivery applications. These applications exploit these promising features of PSi for future translation to the clinic. We will conclude the chapter with a brief overview of our visions of the future of the PSi nanomaterials and their implications in the pharmaceutical and biomedical field.

AB - Micro- and nano-based technologies are presently recognized as promising potential tools for drug delivery applications in almost every field of health sciences, aiming to overcome the adverse physicochemical properties of conventional drug molecules, which often lead to poor drug bioavailability. A large amount of the new chemical entities developed by the pharmaceutical industry are poorly water-soluble compounds, which in order to subsist as efficient drugs with improved and controllable in vivo behaviour require the aid of more advanced technologies. In this context, porous silicon (PSi) nanocarriers have received considerable attention for the delivery of a wide range of therapeutics, particularly due to their excellent in vivo biocompatibility, easy surface chemical modification and easy control over their porous network structure. The literature has extensively demonstrated the successful use of PSi for controlling the loading and release of poorly water-soluble drugs; however, in this chapter we will mainly focus on the applications of the PSi-based nanoparticles for biomedical applications. In this chapter, we start by addressing the issues of poorly water-soluble drugs and then introduce PSi-based materials as potential drug carriers for such drugs. We then highlight the fabrication methodology of PSi materials, the drug loading and release, and present several examples of the significant potential of PSi in biomedical imaging and in drug delivery applications. These applications exploit these promising features of PSi for future translation to the clinic. We will conclude the chapter with a brief overview of our visions of the future of the PSi nanomaterials and their implications in the pharmaceutical and biomedical field.

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KW - drug delivery

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KW - biomedical applications

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M3 - Chapter

SN - 9781461491637

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EP - 275

BT - Fundamentals of Pharmaceutical Nanoscience

A2 - F. Uchegbu, Ijeoma

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Santos HA, Mäkilä E, Bimbo L, Almeida P, Hirvonen J. Porous silicon nanoparticles. In F. Uchegbu I, G. Schätzlein A, Ping Cheng W, Lalatsa A, editors, Fundamentals of Pharmaceutical Nanoscience. New York: Springer Science + Business Media. 2013. p. 235–275 https://doi.org/10.1007%2F978-1-4614-9164-4_10