Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing

Riikka Laukkanen-Ninios, Xavier Didelot, Keith Jolley, Giovanna Morelli, Vartul Sangal, Paula Kristo, Carina Brehony, Priscilla Imori, Hiroshi Fukushima, Anja Siitonen, Galina Tseneva, Ekaterina Voskressenskaya, Juliana Falcao, Hannu Korkeala, Martin Maiden, Camila Mazzoni, Elisabeth Carniel, Mikael Skurnik, Mark Achtman

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status [Y. pseudotuberculosis sensu stricto (s.s.), Yersinia pestis and Yersinia similis] and a fourth population, which we refer to as the Korean group, which may be in the process of speciation. We detected clear signs of recombination within Y. pseudotuberculosis s.s. as well as imports from Y. similis and the Korean group. The sources of genetic diversification within Y. pseudotuberculosis s.s. were approximately equally divided between recombination and mutation, whereas recombination has not yet been demonstrated in Y. pestis, which is also much more genetically monomorphic than is Y. pseudotuberculosis s.s. Most Y. pseudotuberculosis s.s. belong to a diffuse group of sequence types lacking clear population structure, although this species contains a melibiose-negative clade that is present globally in domesticated animals. Yersinia similis corresponds to the previously identified Y. pseudotuberculosis genetic type G4, which is probably not pathogenic because it lacks the virulence factors that are typical for Y. pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans.
LanguageEnglish
Pages3114-3127
Number of pages14
JournalEnvironmental Microbiology
Volume13
Issue number12
DOIs
Publication statusPublished - 2011

Fingerprint

Yersinia pseudotuberculosis
Multilocus Sequence Typing
recombination
population structure
Population
Yersinia pestis
virulence
Genetic Recombination
import
Yersinia
mutation
Melibiose
melibiose
multilocus sequence typing
Domestic Animals
Virulence Factors
human diseases
imports

Keywords

  • Yersinia pseudotuberculosis
  • multilocus sequence typing
  • microbiology

Cite this

Laukkanen-Ninios, R., Didelot, X., Jolley, K., Morelli, G., Sangal, V., Kristo, P., ... Achtman, M. (2011). Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing. Environmental Microbiology, 13(12), 3114-3127. https://doi.org/10.1111/j.1462-2920.2011.02588.x
Laukkanen-Ninios, Riikka ; Didelot, Xavier ; Jolley, Keith ; Morelli, Giovanna ; Sangal, Vartul ; Kristo, Paula ; Brehony, Carina ; Imori, Priscilla ; Fukushima, Hiroshi ; Siitonen, Anja ; Tseneva, Galina ; Voskressenskaya, Ekaterina ; Falcao, Juliana ; Korkeala, Hannu ; Maiden, Martin ; Mazzoni, Camila ; Carniel, Elisabeth ; Skurnik, Mikael ; Achtman, Mark. / Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing. In: Environmental Microbiology. 2011 ; Vol. 13, No. 12. pp. 3114-3127.
@article{ec559d46d7ed42a58a88071c17c34a0b,
title = "Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing",
abstract = "Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status [Y. pseudotuberculosis sensu stricto (s.s.), Yersinia pestis and Yersinia similis] and a fourth population, which we refer to as the Korean group, which may be in the process of speciation. We detected clear signs of recombination within Y. pseudotuberculosis s.s. as well as imports from Y. similis and the Korean group. The sources of genetic diversification within Y. pseudotuberculosis s.s. were approximately equally divided between recombination and mutation, whereas recombination has not yet been demonstrated in Y. pestis, which is also much more genetically monomorphic than is Y. pseudotuberculosis s.s. Most Y. pseudotuberculosis s.s. belong to a diffuse group of sequence types lacking clear population structure, although this species contains a melibiose-negative clade that is present globally in domesticated animals. Yersinia similis corresponds to the previously identified Y. pseudotuberculosis genetic type G4, which is probably not pathogenic because it lacks the virulence factors that are typical for Y. pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans.",
keywords = "Yersinia pseudotuberculosis , multilocus sequence typing , microbiology",
author = "Riikka Laukkanen-Ninios and Xavier Didelot and Keith Jolley and Giovanna Morelli and Vartul Sangal and Paula Kristo and Carina Brehony and Priscilla Imori and Hiroshi Fukushima and Anja Siitonen and Galina Tseneva and Ekaterina Voskressenskaya and Juliana Falcao and Hannu Korkeala and Martin Maiden and Camila Mazzoni and Elisabeth Carniel and Mikael Skurnik and Mark Achtman",
year = "2011",
doi = "10.1111/j.1462-2920.2011.02588.x",
language = "English",
volume = "13",
pages = "3114--3127",
journal = "Environmental Microbiology",
issn = "1462-2920",
number = "12",

}

Laukkanen-Ninios, R, Didelot, X, Jolley, K, Morelli, G, Sangal, V, Kristo, P, Brehony, C, Imori, P, Fukushima, H, Siitonen, A, Tseneva, G, Voskressenskaya, E, Falcao, J, Korkeala, H, Maiden, M, Mazzoni, C, Carniel, E, Skurnik, M & Achtman, M 2011, 'Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing' Environmental Microbiology, vol. 13, no. 12, pp. 3114-3127. https://doi.org/10.1111/j.1462-2920.2011.02588.x

Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing. / Laukkanen-Ninios, Riikka ; Didelot, Xavier; Jolley, Keith; Morelli, Giovanna ; Sangal, Vartul; Kristo, Paula ; Brehony, Carina ; Imori, Priscilla; Fukushima, Hiroshi ; Siitonen, Anja ; Tseneva, Galina ; Voskressenskaya, Ekaterina ; Falcao, Juliana; Korkeala, Hannu ; Maiden, Martin; Mazzoni, Camila ; Carniel, Elisabeth ; Skurnik, Mikael ; Achtman, Mark.

In: Environmental Microbiology, Vol. 13, No. 12, 2011, p. 3114-3127.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing

AU - Laukkanen-Ninios, Riikka

AU - Didelot, Xavier

AU - Jolley, Keith

AU - Morelli, Giovanna

AU - Sangal, Vartul

AU - Kristo, Paula

AU - Brehony, Carina

AU - Imori, Priscilla

AU - Fukushima, Hiroshi

AU - Siitonen, Anja

AU - Tseneva, Galina

AU - Voskressenskaya, Ekaterina

AU - Falcao, Juliana

AU - Korkeala, Hannu

AU - Maiden, Martin

AU - Mazzoni, Camila

AU - Carniel, Elisabeth

AU - Skurnik, Mikael

AU - Achtman, Mark

PY - 2011

Y1 - 2011

N2 - Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status [Y. pseudotuberculosis sensu stricto (s.s.), Yersinia pestis and Yersinia similis] and a fourth population, which we refer to as the Korean group, which may be in the process of speciation. We detected clear signs of recombination within Y. pseudotuberculosis s.s. as well as imports from Y. similis and the Korean group. The sources of genetic diversification within Y. pseudotuberculosis s.s. were approximately equally divided between recombination and mutation, whereas recombination has not yet been demonstrated in Y. pestis, which is also much more genetically monomorphic than is Y. pseudotuberculosis s.s. Most Y. pseudotuberculosis s.s. belong to a diffuse group of sequence types lacking clear population structure, although this species contains a melibiose-negative clade that is present globally in domesticated animals. Yersinia similis corresponds to the previously identified Y. pseudotuberculosis genetic type G4, which is probably not pathogenic because it lacks the virulence factors that are typical for Y. pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans.

AB - Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status [Y. pseudotuberculosis sensu stricto (s.s.), Yersinia pestis and Yersinia similis] and a fourth population, which we refer to as the Korean group, which may be in the process of speciation. We detected clear signs of recombination within Y. pseudotuberculosis s.s. as well as imports from Y. similis and the Korean group. The sources of genetic diversification within Y. pseudotuberculosis s.s. were approximately equally divided between recombination and mutation, whereas recombination has not yet been demonstrated in Y. pestis, which is also much more genetically monomorphic than is Y. pseudotuberculosis s.s. Most Y. pseudotuberculosis s.s. belong to a diffuse group of sequence types lacking clear population structure, although this species contains a melibiose-negative clade that is present globally in domesticated animals. Yersinia similis corresponds to the previously identified Y. pseudotuberculosis genetic type G4, which is probably not pathogenic because it lacks the virulence factors that are typical for Y. pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans.

KW - Yersinia pseudotuberculosis

KW - multilocus sequence typing

KW - microbiology

UR - http://www.scopus.com/inward/record.url?scp=82555187981&partnerID=8YFLogxK

U2 - 10.1111/j.1462-2920.2011.02588.x

DO - 10.1111/j.1462-2920.2011.02588.x

M3 - Article

VL - 13

SP - 3114

EP - 3127

JO - Environmental Microbiology

T2 - Environmental Microbiology

JF - Environmental Microbiology

SN - 1462-2920

IS - 12

ER -