Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis

Stephanie Hennig; Joseph Stanning; Christine Staatz; Alison Thomson

doi:10.1007/s40262-013-0036-y

Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis

Stephanie Hennig, Joseph Stanning, Christine Staatz, Alison Thomson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

While several studies have examined the pharmacokinetics of tobramycin in patients with cystic fibrosis (CF), there is no consensus on whether they differ in patients with and without CF. The objectives of this study were to identify covariates which explain pharmacokinetic variability and to examine whether having the disease CF in itself alters these relationships and drug dose requirements.

Original language	English
Pages (from-to)	289-301
Number of pages	13
Journal	Clinical Pharmacokinetics
Volume	52
Issue number	4
DOIs	https://doi.org/10.1007/s40262-013-0036-y
Publication status	Published - 1 Apr 2013

Keywords

tobramycin
cystic fibrosis
pharmacokinetics
pharmacometrics
patients

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10.1007/s40262-013-0036-y

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abstract = "While several studies have examined the pharmacokinetics of tobramycin in patients with cystic fibrosis (CF), there is no consensus on whether they differ in patients with and without CF. The objectives of this study were to identify covariates which explain pharmacokinetic variability and to examine whether having the disease CF in itself alters these relationships and drug dose requirements.",

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AB - While several studies have examined the pharmacokinetics of tobramycin in patients with cystic fibrosis (CF), there is no consensus on whether they differ in patients with and without CF. The objectives of this study were to identify covariates which explain pharmacokinetic variability and to examine whether having the disease CF in itself alters these relationships and drug dose requirements.

KW - tobramycin

KW - cystic fibrosis

KW - pharmacokinetics

KW - pharmacometrics

KW - patients

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DO - 10.1007/s40262-013-0036-y

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JO - Clinical Pharmacokinetics

JF - Clinical Pharmacokinetics

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Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis

Abstract

Keywords

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