Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis

Stephanie Hennig, Joseph Stanning, Christine Staatz, Alison Thomson

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

While several studies have examined the pharmacokinetics of tobramycin in patients with cystic fibrosis (CF), there is no consensus on whether they differ in patients with and without CF. The objectives of this study were to identify covariates which explain pharmacokinetic variability and to examine whether having the disease CF in itself alters these relationships and drug dose requirements.
Original languageEnglish
Pages (from-to)289-301
Number of pages13
JournalClinical Pharmacokinetics
Volume52
Issue number4
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • tobramycin
  • cystic fibrosis
  • pharmacokinetics
  • pharmacometrics
  • patients

Cite this