Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts

Mohamed S. Marzouk, Fatma A. Moharram, Rabab A. El Dib, Siham M. El-Shenawy, Ahmed F. Tawfike

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two new flavonol glycosides, myricetin 4'-O-α-L-rhamnopyranoside (1) and quercetin 3'-O-α-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-L-1C4-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg-1b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin(4) and hyperin(7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.
LanguageEnglish
Pages1456-1467
Number of pages12
JournalMolecules
Volume14
Issue number4
DOIs
Publication statusPublished - 7 Apr 2009

Fingerprint

Oenothera
Bioactivity
Methanol
Chlorogenic Acid
Antennas
Onagraceae
Ellagic Acid
Gallic Acid
Quercetin
Glycosides
Chloroform
Metabolites
Hypoglycemic Agents
Assays
Esters
Anti-Inflammatory Agents
Antioxidants
Nuclear magnetic resonance
hyperoside
myricitrin

Keywords

  • antioxidant
  • polyphenolic compounds
  • flavonoids
  • Oenothera speciosa

Cite this

Marzouk, M. S., Moharram, F. A., El Dib, R. A., El-Shenawy, S. M., & Tawfike, A. F. (2009). Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts. Molecules, 14(4), 1456-1467. https://doi.org/10.3390/molecules14041456
Marzouk, Mohamed S. ; Moharram, Fatma A. ; El Dib, Rabab A. ; El-Shenawy, Siham M. ; Tawfike, Ahmed F. / Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts. In: Molecules. 2009 ; Vol. 14, No. 4. pp. 1456-1467.
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Marzouk, MS, Moharram, FA, El Dib, RA, El-Shenawy, SM & Tawfike, AF 2009, 'Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts' Molecules, vol. 14, no. 4, pp. 1456-1467. https://doi.org/10.3390/molecules14041456

Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts. / Marzouk, Mohamed S.; Moharram, Fatma A.; El Dib, Rabab A.; El-Shenawy, Siham M.; Tawfike, Ahmed F.

In: Molecules, Vol. 14, No. 4, 07.04.2009, p. 1456-1467.

Research output: Contribution to journalArticle

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AU - Marzouk, Mohamed S.

AU - Moharram, Fatma A.

AU - El Dib, Rabab A.

AU - El-Shenawy, Siham M.

AU - Tawfike, Ahmed F.

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Marzouk MS, Moharram FA, El Dib RA, El-Shenawy SM, Tawfike AF. Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts. Molecules. 2009 Apr 7;14(4):1456-1467. https://doi.org/10.3390/molecules14041456