Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison; Amit Delori; Xiao Wang; Konstantin V. Kamenev; Andrew J. Urquhart; Iain D.H. Oswald

doi:10.1039/C5CE00119F

Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison, Amit Delori, Xiao Wang, Konstantin V. Kamenev, Andrew J. Urquhart, Iain D.H. Oswald

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

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Abstract

A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

Original language	English
Pages (from-to)	1778 - 1782
Number of pages	4
Journal	CrystEngComm
Volume	17
Issue number	8
Early online date	20 Jan 2015
DOIs	https://doi.org/10.1039/C5CE00119F
Publication status	Published - 2015

Keywords

glycolide
polyglycolic acid
crystallisation

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10.1039/C5CE00119F

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Iain Oswald
- iain.oswald@strath.ac.uk
- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Reader
Person: Academic

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title = "Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments",

abstract = "A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.",

keywords = "glycolide, polyglycolic acid, crystallisation",

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AU - Hutchison, Ian B.

AU - Delori, Amit

AU - Wang, Xiao

AU - Kamenev, Konstantin V.

AU - Urquhart, Andrew J.

AU - Oswald, Iain D.H.

PY - 2015

Y1 - 2015

N2 - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

AB - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

KW - glycolide

KW - polyglycolic acid

KW - crystallisation

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DO - 10.1039/C5CE00119F

M3 - Article

VL - 17

SP - 1778

EP - 1782

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 8

ER -

Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Abstract

Keywords

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Iain Oswald

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