Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison, Amit Delori, Xiao Wang, Konstantin V. Kamenev, Andrew J. Urquhart, Iain D.H. Oswald

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.
LanguageEnglish
Pages1778 - 1782
Number of pages4
JournalCrystEngComm
Volume17
Issue number8
Early online date20 Jan 2015
DOIs
Publication statusPublished - 2015

Fingerprint

polymorphism
Polymorphism
seeds
Polymers
crystallization
acids
polymers
Experiments
Polyglycolic Acid
Crystallization
Seed
Acids

Keywords

  • glycolide
  • polyglycolic acid
  • crystallisation

Cite this

Hutchison, Ian B. ; Delori, Amit ; Wang, Xiao ; Kamenev, Konstantin V. ; Urquhart, Andrew J. ; Oswald, Iain D.H. / Polymorphism of a polymer pre-cursor : metastable glycolide polymorph recovered via large scale high-pressure experiments. In: CrystEngComm. 2015 ; Vol. 17, No. 8. pp. 1778 - 1782.
@article{b323e4085f6e4d05adb8690951dc0055,
title = "Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments",
abstract = "A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.",
keywords = "glycolide, polyglycolic acid, crystallisation",
author = "Hutchison, {Ian B.} and Amit Delori and Xiao Wang and Kamenev, {Konstantin V.} and Urquhart, {Andrew J.} and Oswald, {Iain D.H.}",
year = "2015",
doi = "10.1039/C5CE00119F",
language = "English",
volume = "17",
pages = "1778 -- 1782",
journal = "CrystEngComm",
issn = "1466-8033",
number = "8",

}

Polymorphism of a polymer pre-cursor : metastable glycolide polymorph recovered via large scale high-pressure experiments. / Hutchison, Ian B.; Delori, Amit; Wang, Xiao; Kamenev, Konstantin V.; Urquhart, Andrew J.; Oswald, Iain D.H.

In: CrystEngComm, Vol. 17, No. 8, 2015, p. 1778 - 1782.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphism of a polymer pre-cursor

T2 - CrystEngComm

AU - Hutchison, Ian B.

AU - Delori, Amit

AU - Wang, Xiao

AU - Kamenev, Konstantin V.

AU - Urquhart, Andrew J.

AU - Oswald, Iain D.H.

PY - 2015

Y1 - 2015

N2 - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

AB - A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.

KW - glycolide

KW - polyglycolic acid

KW - crystallisation

U2 - 10.1039/C5CE00119F

DO - 10.1039/C5CE00119F

M3 - Article

VL - 17

SP - 1778

EP - 1782

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 8

ER -