Polymorphism of a polymer pre-cursor: metastable glycolide polymorph recovered via large scale high-pressure experiments

Ian B. Hutchison, Amit Delori, Xiao Wang, Konstantin V. Kamenev, Andrew J. Urquhart, Iain D.H. Oswald

Research output: Contribution to journalArticle

10 Citations (Scopus)
26 Downloads (Pure)

Abstract

A novel polymorph of glycolide, the precursor to polyglycolic acid, has been observed at 0.6 GPa. Large scale high-pressure production has been performed and the seeds successfully used to aid crystallisation of the polymorph at ambient pressure. PIXEL calculations confirm the metastable nature of the polymorph. Subsequent experiments show that, whilst initially stable for 12 days, this may be a case of disappearing polymorphism.
Original languageEnglish
Pages (from-to)1778 - 1782
Number of pages4
JournalCrystEngComm
Volume17
Issue number8
Early online date20 Jan 2015
DOIs
Publication statusPublished - 2015

Keywords

  • glycolide
  • polyglycolic acid
  • crystallisation

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