Projects per year
Abstract
We review the polymorphism of p-aminobenzoic acid (pABA), a model drug compound whose crystallisation and polymorphic behaviour has been extensively studied in recent years. Beyond the well-known and characterised α and β forms, pABA also crystallises as a γ polymorph, which is structurally similar to the α form. In addition we also compare the newly reported δ form, obtained by high pressure crystallisation and through compression of the α-form. A structural analysis and comparison of all of the forms is presented, the conditions by which each of them is obtained summarised. Crystal structure prediction calculations have also been carried out in order to probe the solid form energy landscape of this compound. The overall picture of the polymorphism of pABA, reveals, surprisingly, the rarity of the β form.
Original language | English |
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Pages (from-to) | 2034-2042 |
Number of pages | 9 |
Journal | CrystEngComm |
Volume | 21 |
Issue number | 13 |
Early online date | 22 Jan 2019 |
DOIs | |
Publication status | Published - 7 Apr 2019 |
Keywords
- p-aminobenzoic acid
- polymorph
- review
Fingerprint
Dive into the research topics of 'Polymorphism in p-aminobenzoic acid'. Together they form a unique fingerprint.Projects
- 1 Finished
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Pressure-Induced Nucleation for the Continuous Manufacture of Supramolecular assemblies
Sefcik, J. (Co-investigator), Ter Horst, J. (Co-investigator) & Oswald, I. (Fellow)
EPSRC (Engineering and Physical Sciences Research Council)
1/06/16 → 30/11/22
Project: Research Fellowship
Datasets
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Discovery of delta polymorph of para-aminobenzoic acid
Ward, M. (Creator), Younis, S. (Contributor), Cruz-Cabeza, A. (Contributor), Bull, C. L. (Contributor), Funnell, N. (Contributor) & Oswald, I. (Creator), University of Strathclyde, 21 Jan 2019
DOI: 10.15129/37add8c9-2655-43e9-b162-9f6338265702
Dataset
Research output
- 36 Citations
- 1 Article
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Discovery and recovery of delta p-aminobenzoic acid
Ward, M. R., Younis, S., Cruz-Cabeza, A. J., Bull, C. L., Funnell, N. P. & Oswald, I. D. H., 7 Apr 2019, In: CrystEngComm. 21, 13, p. 2058-2066 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)75 Downloads (Pure)
Activities
- 1 Oral presentation
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Recovery of high pressure solid forms to ambient pressure
Ward, M. (Speaker)
9 Jul 2019Activity: Talk or presentation types › Oral presentation