Polymorphism in p-aminobenzoic acid

Aurora J. Cruz-Cabeza, Roger J. Davey, Iain D.H. Oswald, Martin R. Ward, Isaac J. Sugden

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
22 Downloads (Pure)

Abstract

We review the polymorphism of p-aminobenzoic acid (pABA), a model drug compound whose crystallisation and polymorphic behaviour has been extensively studied in recent years. Beyond the well-known and characterised α and β forms, pABA also crystallises as a γ polymorph, which is structurally similar to the α form. In addition we also compare the newly reported δ form, obtained by high pressure crystallisation and through compression of the α-form. A structural analysis and comparison of all of the forms is presented, the conditions by which each of them is obtained summarised. Crystal structure prediction calculations have also been carried out in order to probe the solid form energy landscape of this compound. The overall picture of the polymorphism of pABA, reveals, surprisingly, the rarity of the β form.
Original languageEnglish
Pages (from-to)2034-2042
Number of pages9
JournalCrystEngComm
Volume21
Issue number13
Early online date22 Jan 2019
DOIs
Publication statusPublished - 7 Apr 2019

Keywords

  • p-aminobenzoic acid
  • polymorph
  • review

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