Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III

H. Polyzois, R. Guo, M. Warzecha, S. L. Price, A. Florence

Research output: Contribution to conferencePoster

Abstract

Crystal structures exhibiting twisted morphology have been observed at the nanoscale, mesoscale, and macroscale and are challenging to characterise structurally because of their lack of long-range translational symmetry [1]. Crystal structure prediction (CSP) studies of an active pharmaceutical ingredient’s lattice energy landscape are often utilised for assisting experimentalists in identifying and characterising novel polymorphic forms that are thermodynamically feasible, including ones that crystallise with twisted morphologies [2-4].
Oxcarbazepine (OXCBZ) is a commercially available pharmaceutical used for the treatment of epilepsy and three polymorphic forms have been reported, two of which (form I and form II) are known to crystallise in the monoclinic space groups P21/c and P21 respectively [5]. Form III of OXCBZ was originally prepared by slow evaporation from methanol solutions that contained polymer additives but structure solution was not possible because of the small size and poor quality of the crystals.
Herein, we present experimental protocols for the crystallization of OXCBZ III from both solution and the vapour phase. In our work, we combined CSP studies of OXCBZ with physical vapour deposition studies and solution-based polymorph screening experiments. Needle-like and fibre-like crystals of OXCBZ III exhibiting variable twisted habit emerged from vapour deposition of OXCBZ onto metallic substrates. Scanning electron and atomic force microscopy studies have been carried out to obtain an insight into the mechanism of formation and growth of the twisted OXCBZ III crystals over the course of the deposition process.

Conference

ConferenceGordon Research Conference on Crystal Growth and Assembly
CountryUnited States
CityManchester
Period23/06/1928/06/19

Fingerprint

Polymorphism
Screening
Crystals
Crystal structure
Drug products
Vapor deposition
Crystal symmetry
Physical vapor deposition
Needles
Atomic force microscopy
Evaporation
Methanol
Crystallization
Vapors
Scanning
oxcarbazepine
Electrons
Fibers
Pharmaceutical Preparations
Polymers

Keywords

  • oxcarbazepine
  • pharmaceutical polymorphism
  • crystal structure prediction
  • twisted crystal habit

Cite this

Polyzois, H., Guo, R., Warzecha, M., Price, S. L., & Florence, A. (2019). Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III. Poster session presented at Gordon Research Conference on Crystal Growth and Assembly , Manchester, United States.
Polyzois, H. ; Guo, R. ; Warzecha, M. ; Price, S. L. ; Florence, A. / Polymorph screening studies of oxcarbazepine : twisted habit in crystals of the elusive form III. Poster session presented at Gordon Research Conference on Crystal Growth and Assembly , Manchester, United States.1 p.
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title = "Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III",
abstract = "Crystal structures exhibiting twisted morphology have been observed at the nanoscale, mesoscale, and macroscale and are challenging to characterise structurally because of their lack of long-range translational symmetry [1]. Crystal structure prediction (CSP) studies of an active pharmaceutical ingredient’s lattice energy landscape are often utilised for assisting experimentalists in identifying and characterising novel polymorphic forms that are thermodynamically feasible, including ones that crystallise with twisted morphologies [2-4].Oxcarbazepine (OXCBZ) is a commercially available pharmaceutical used for the treatment of epilepsy and three polymorphic forms have been reported, two of which (form I and form II) are known to crystallise in the monoclinic space groups P21/c and P21 respectively [5]. Form III of OXCBZ was originally prepared by slow evaporation from methanol solutions that contained polymer additives but structure solution was not possible because of the small size and poor quality of the crystals.Herein, we present experimental protocols for the crystallization of OXCBZ III from both solution and the vapour phase. In our work, we combined CSP studies of OXCBZ with physical vapour deposition studies and solution-based polymorph screening experiments. Needle-like and fibre-like crystals of OXCBZ III exhibiting variable twisted habit emerged from vapour deposition of OXCBZ onto metallic substrates. Scanning electron and atomic force microscopy studies have been carried out to obtain an insight into the mechanism of formation and growth of the twisted OXCBZ III crystals over the course of the deposition process.",
keywords = "oxcarbazepine, pharmaceutical polymorphism, crystal structure prediction, twisted crystal habit",
author = "H. Polyzois and R. Guo and M. Warzecha and Price, {S. L.} and A. Florence",
year = "2019",
month = "6",
day = "23",
language = "English",
note = "Gordon Research Conference on Crystal Growth and Assembly ; Conference date: 23-06-2019 Through 28-06-2019",

}

Polyzois, H, Guo, R, Warzecha, M, Price, SL & Florence, A 2019, 'Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III' Gordon Research Conference on Crystal Growth and Assembly , Manchester, United States, 23/06/19 - 28/06/19, .

Polymorph screening studies of oxcarbazepine : twisted habit in crystals of the elusive form III. / Polyzois, H.; Guo, R.; Warzecha, M.; Price, S. L.; Florence, A.

2019. Poster session presented at Gordon Research Conference on Crystal Growth and Assembly , Manchester, United States.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Polymorph screening studies of oxcarbazepine

T2 - twisted habit in crystals of the elusive form III

AU - Polyzois, H.

AU - Guo, R.

AU - Warzecha, M.

AU - Price, S. L.

AU - Florence, A.

PY - 2019/6/23

Y1 - 2019/6/23

N2 - Crystal structures exhibiting twisted morphology have been observed at the nanoscale, mesoscale, and macroscale and are challenging to characterise structurally because of their lack of long-range translational symmetry [1]. Crystal structure prediction (CSP) studies of an active pharmaceutical ingredient’s lattice energy landscape are often utilised for assisting experimentalists in identifying and characterising novel polymorphic forms that are thermodynamically feasible, including ones that crystallise with twisted morphologies [2-4].Oxcarbazepine (OXCBZ) is a commercially available pharmaceutical used for the treatment of epilepsy and three polymorphic forms have been reported, two of which (form I and form II) are known to crystallise in the monoclinic space groups P21/c and P21 respectively [5]. Form III of OXCBZ was originally prepared by slow evaporation from methanol solutions that contained polymer additives but structure solution was not possible because of the small size and poor quality of the crystals.Herein, we present experimental protocols for the crystallization of OXCBZ III from both solution and the vapour phase. In our work, we combined CSP studies of OXCBZ with physical vapour deposition studies and solution-based polymorph screening experiments. Needle-like and fibre-like crystals of OXCBZ III exhibiting variable twisted habit emerged from vapour deposition of OXCBZ onto metallic substrates. Scanning electron and atomic force microscopy studies have been carried out to obtain an insight into the mechanism of formation and growth of the twisted OXCBZ III crystals over the course of the deposition process.

AB - Crystal structures exhibiting twisted morphology have been observed at the nanoscale, mesoscale, and macroscale and are challenging to characterise structurally because of their lack of long-range translational symmetry [1]. Crystal structure prediction (CSP) studies of an active pharmaceutical ingredient’s lattice energy landscape are often utilised for assisting experimentalists in identifying and characterising novel polymorphic forms that are thermodynamically feasible, including ones that crystallise with twisted morphologies [2-4].Oxcarbazepine (OXCBZ) is a commercially available pharmaceutical used for the treatment of epilepsy and three polymorphic forms have been reported, two of which (form I and form II) are known to crystallise in the monoclinic space groups P21/c and P21 respectively [5]. Form III of OXCBZ was originally prepared by slow evaporation from methanol solutions that contained polymer additives but structure solution was not possible because of the small size and poor quality of the crystals.Herein, we present experimental protocols for the crystallization of OXCBZ III from both solution and the vapour phase. In our work, we combined CSP studies of OXCBZ with physical vapour deposition studies and solution-based polymorph screening experiments. Needle-like and fibre-like crystals of OXCBZ III exhibiting variable twisted habit emerged from vapour deposition of OXCBZ onto metallic substrates. Scanning electron and atomic force microscopy studies have been carried out to obtain an insight into the mechanism of formation and growth of the twisted OXCBZ III crystals over the course of the deposition process.

KW - oxcarbazepine

KW - pharmaceutical polymorphism

KW - crystal structure prediction

KW - twisted crystal habit

UR - https://www.grc.org/crystal-growth-and-assembly-conference/2019/

M3 - Poster

ER -

Polyzois H, Guo R, Warzecha M, Price SL, Florence A. Polymorph screening studies of oxcarbazepine: twisted habit in crystals of the elusive form III. 2019. Poster session presented at Gordon Research Conference on Crystal Growth and Assembly , Manchester, United States.