Polymeric particulates for subunit vaccine delivery

Thomas Schuster, Martin Nussbaumer, Patric Baumann, Nico Bruns, Wolfgang Meier, Anja Car

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Vaccines still represent the best long-term treatment option for reducing many infectious diseases, including acquired immune deficiency syndrome (AIDS), malaria, and tuberculosis. Therefore, to effectively combat these severe diseases, it is of utmost importance to develop and explore novel and more efficient delivery modalities and administration routes. In this context, new polymeric nano- and microparticulate delivery platforms may represent an alternative and/or complementary therapeutic option. With the help of modern polymer chemistry, an increased number of sophisticated architectures have been developed, although these materials are in terms of bio applications still in relatively early stages. Therefore, a lot of recent attention has been dedicated to designing and tailoring novel particulates delivery systems with focus to create more efficient delivery platform. Various structures, including nanogels, nanocapsules, nano- and microparticles, dendrimers, and different hierarchical assemblies in solution have been studied in vaccine delivery. However, none of these explored platforms until now fully complies with basic delivery requirements like biocompatibility, non-toxicity, high encapsulation efficiency, and the ability to induce prolonged immune responses. In general, the unique structural and mechanical properties of polymers and their abilities to create three-dimensional structures or hybrid systems is under intensive investigation and hold a great promise in vaccine delivery.
Original languageEnglish
Title of host publicationSubunit Vaccine Delivery
EditorsCamilla Foged, Thomas Rades, Yvonne Perrie, Sarah Hook
Place of PublicationNew York
PublisherSpringer
Pages181-201
Number of pages21
ISBN (Print)9781493914166, 9781493914173
DOIs
Publication statusPublished - 31 Dec 2014

Publication series

Name Advances in Delivery Science and Technology
PublisherSpringer

Fingerprint

Subunit Vaccines
Vaccines
Polymers
Nanocapsules
Dendrimers
Hybrid systems
Biocompatibility
Encapsulation
Nanoparticles
Malaria
Communicable Diseases
Structural properties
Acquired Immunodeficiency Syndrome
Tuberculosis
Mechanical properties
Therapeutics

Keywords

  • human serum albumin
  • major histocompatibility complex class
  • acquire immune deficiency syndrome
  • vaccine delivery
  • delivery platform

Cite this

Schuster, T., Nussbaumer, M., Baumann, P., Bruns, N., Meier, W., & Car, A. (2014). Polymeric particulates for subunit vaccine delivery. In C. Foged, T. Rades, Y. Perrie, & S. Hook (Eds.), Subunit Vaccine Delivery (pp. 181-201). ( Advances in Delivery Science and Technology). New York: Springer. https://doi.org/10.1007/978-1-4939-1417-3_10
Schuster, Thomas ; Nussbaumer, Martin ; Baumann, Patric ; Bruns, Nico ; Meier, Wolfgang ; Car, Anja. / Polymeric particulates for subunit vaccine delivery. Subunit Vaccine Delivery. editor / Camilla Foged ; Thomas Rades ; Yvonne Perrie ; Sarah Hook. New York : Springer, 2014. pp. 181-201 ( Advances in Delivery Science and Technology).
@inbook{0d1bf286412144b9b3f66cca76dcb2d5,
title = "Polymeric particulates for subunit vaccine delivery",
abstract = "Vaccines still represent the best long-term treatment option for reducing many infectious diseases, including acquired immune deficiency syndrome (AIDS), malaria, and tuberculosis. Therefore, to effectively combat these severe diseases, it is of utmost importance to develop and explore novel and more efficient delivery modalities and administration routes. In this context, new polymeric nano- and microparticulate delivery platforms may represent an alternative and/or complementary therapeutic option. With the help of modern polymer chemistry, an increased number of sophisticated architectures have been developed, although these materials are in terms of bio applications still in relatively early stages. Therefore, a lot of recent attention has been dedicated to designing and tailoring novel particulates delivery systems with focus to create more efficient delivery platform. Various structures, including nanogels, nanocapsules, nano- and microparticles, dendrimers, and different hierarchical assemblies in solution have been studied in vaccine delivery. However, none of these explored platforms until now fully complies with basic delivery requirements like biocompatibility, non-toxicity, high encapsulation efficiency, and the ability to induce prolonged immune responses. In general, the unique structural and mechanical properties of polymers and their abilities to create three-dimensional structures or hybrid systems is under intensive investigation and hold a great promise in vaccine delivery.",
keywords = "human serum albumin, major histocompatibility complex class, acquire immune deficiency syndrome, vaccine delivery, delivery platform",
author = "Thomas Schuster and Martin Nussbaumer and Patric Baumann and Nico Bruns and Wolfgang Meier and Anja Car",
year = "2014",
month = "12",
day = "31",
doi = "10.1007/978-1-4939-1417-3_10",
language = "English",
isbn = "9781493914166",
series = "Advances in Delivery Science and Technology",
publisher = "Springer",
pages = "181--201",
editor = "Camilla Foged and Thomas Rades and Yvonne Perrie and Sarah Hook",
booktitle = "Subunit Vaccine Delivery",

}

Schuster, T, Nussbaumer, M, Baumann, P, Bruns, N, Meier, W & Car, A 2014, Polymeric particulates for subunit vaccine delivery. in C Foged, T Rades, Y Perrie & S Hook (eds), Subunit Vaccine Delivery. Advances in Delivery Science and Technology, Springer, New York, pp. 181-201. https://doi.org/10.1007/978-1-4939-1417-3_10

Polymeric particulates for subunit vaccine delivery. / Schuster, Thomas; Nussbaumer, Martin; Baumann, Patric; Bruns, Nico; Meier, Wolfgang; Car, Anja.

Subunit Vaccine Delivery. ed. / Camilla Foged; Thomas Rades; Yvonne Perrie; Sarah Hook. New York : Springer, 2014. p. 181-201 ( Advances in Delivery Science and Technology).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Polymeric particulates for subunit vaccine delivery

AU - Schuster, Thomas

AU - Nussbaumer, Martin

AU - Baumann, Patric

AU - Bruns, Nico

AU - Meier, Wolfgang

AU - Car, Anja

PY - 2014/12/31

Y1 - 2014/12/31

N2 - Vaccines still represent the best long-term treatment option for reducing many infectious diseases, including acquired immune deficiency syndrome (AIDS), malaria, and tuberculosis. Therefore, to effectively combat these severe diseases, it is of utmost importance to develop and explore novel and more efficient delivery modalities and administration routes. In this context, new polymeric nano- and microparticulate delivery platforms may represent an alternative and/or complementary therapeutic option. With the help of modern polymer chemistry, an increased number of sophisticated architectures have been developed, although these materials are in terms of bio applications still in relatively early stages. Therefore, a lot of recent attention has been dedicated to designing and tailoring novel particulates delivery systems with focus to create more efficient delivery platform. Various structures, including nanogels, nanocapsules, nano- and microparticles, dendrimers, and different hierarchical assemblies in solution have been studied in vaccine delivery. However, none of these explored platforms until now fully complies with basic delivery requirements like biocompatibility, non-toxicity, high encapsulation efficiency, and the ability to induce prolonged immune responses. In general, the unique structural and mechanical properties of polymers and their abilities to create three-dimensional structures or hybrid systems is under intensive investigation and hold a great promise in vaccine delivery.

AB - Vaccines still represent the best long-term treatment option for reducing many infectious diseases, including acquired immune deficiency syndrome (AIDS), malaria, and tuberculosis. Therefore, to effectively combat these severe diseases, it is of utmost importance to develop and explore novel and more efficient delivery modalities and administration routes. In this context, new polymeric nano- and microparticulate delivery platforms may represent an alternative and/or complementary therapeutic option. With the help of modern polymer chemistry, an increased number of sophisticated architectures have been developed, although these materials are in terms of bio applications still in relatively early stages. Therefore, a lot of recent attention has been dedicated to designing and tailoring novel particulates delivery systems with focus to create more efficient delivery platform. Various structures, including nanogels, nanocapsules, nano- and microparticles, dendrimers, and different hierarchical assemblies in solution have been studied in vaccine delivery. However, none of these explored platforms until now fully complies with basic delivery requirements like biocompatibility, non-toxicity, high encapsulation efficiency, and the ability to induce prolonged immune responses. In general, the unique structural and mechanical properties of polymers and their abilities to create three-dimensional structures or hybrid systems is under intensive investigation and hold a great promise in vaccine delivery.

KW - human serum albumin

KW - major histocompatibility complex class

KW - acquire immune deficiency syndrome

KW - vaccine delivery

KW - delivery platform

UR - https://link.springer.com/book/10.1007/978-1-4939-1417-3

U2 - 10.1007/978-1-4939-1417-3_10

DO - 10.1007/978-1-4939-1417-3_10

M3 - Chapter

SN - 9781493914166

SN - 9781493914173

T3 - Advances in Delivery Science and Technology

SP - 181

EP - 201

BT - Subunit Vaccine Delivery

A2 - Foged, Camilla

A2 - Rades, Thomas

A2 - Perrie, Yvonne

A2 - Hook, Sarah

PB - Springer

CY - New York

ER -

Schuster T, Nussbaumer M, Baumann P, Bruns N, Meier W, Car A. Polymeric particulates for subunit vaccine delivery. In Foged C, Rades T, Perrie Y, Hook S, editors, Subunit Vaccine Delivery. New York: Springer. 2014. p. 181-201. ( Advances in Delivery Science and Technology). https://doi.org/10.1007/978-1-4939-1417-3_10