Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies

X.Z. Qu, L. Omar, T.B.H. Le, L. Tetley, K. Bolton, K.W. Chooi, W. Wang, I.F. Uchegbu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Self-assembly is fundamental to the biological function of cells and the fabrication of nanomaterials. However, the origin of the shape of various self-assemblies, such as the shape of cells, is not altogether clear. Polymeric, oligomeric, or low molecular weight amphiphiles are a rich source of nanomaterials, and controlling their self-assembly is the route to tailored nanosystems with specific functionalities. Here, we provide direct evidence that a particular molecular architecture, polymeric branching, leads to a rare form of self-assembly, the planar nanodisc. Cholesterol containing self-assemblies formed from amphiphilic linear or branched cetyl poly(ethylenimine) (Mn 1000 Da) or amphiphilic cetyl poly(propylenimine) dendrimer derivatives (Mn 2000 Da) show that branching, by reducing the hydrophilic headgroup area, alters the shape of the self-assemblies transforming closed 60 nm spherical bilayer vesicles to rare 50 nm × 10 nm planar bilayer discs. Increasing the hydrophilic headgroup area, by the inclusion of methoxy poly(ethylene glycol) moieties into the amphiphilic headgroup, transforms the planar discs to 100 nm spherical bilayer vesicles. This study provides insight into the key role played by molecular shape on molecular self-organization into rare nanodiscs. Copyright © 2010 American Chemical Society
LanguageEnglish
Pages9997-10004
Number of pages7
JournalLangmuir
Volume24
Issue number18
Publication statusPublished - 16 Sep 2008

Fingerprint

Amphiphiles
Self assembly
self assembly
Nanostructured materials
Nanosystems
Dendrimers
Cholesterol
cholesterol
dendrimers
low molecular weights
cells
Polyethylene glycols
glycols
ethylene
Molecular weight
routes
inclusions
Derivatives
Fabrication
fabrication

Keywords

  • polymeric amphiphile branching
  • rare nanodisc shaped planar self-assemblies

Cite this

Qu, X. Z., Omar, L., Le, T. B. H., Tetley, L., Bolton, K., Chooi, K. W., ... Uchegbu, I. F. (2008). Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies. Langmuir, 24(18), 9997-10004.
Qu, X.Z. ; Omar, L. ; Le, T.B.H. ; Tetley, L. ; Bolton, K. ; Chooi, K.W. ; Wang, W. ; Uchegbu, I.F. / Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies. In: Langmuir. 2008 ; Vol. 24, No. 18. pp. 9997-10004.
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Qu, XZ, Omar, L, Le, TBH, Tetley, L, Bolton, K, Chooi, KW, Wang, W & Uchegbu, IF 2008, 'Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies' Langmuir, vol. 24, no. 18, pp. 9997-10004.

Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies. / Qu, X.Z.; Omar, L.; Le, T.B.H.; Tetley, L.; Bolton, K.; Chooi, K.W.; Wang, W.; Uchegbu, I.F.

In: Langmuir, Vol. 24, No. 18, 16.09.2008, p. 9997-10004.

Research output: Contribution to journalArticle

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AU - Omar, L.

AU - Le, T.B.H.

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Qu XZ, Omar L, Le TBH, Tetley L, Bolton K, Chooi KW et al. Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies. Langmuir. 2008 Sep 16;24(18):9997-10004.