Abstract
OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.
METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.
KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.
CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.
| Language | English |
|---|---|
| Pages | 167-172 |
| Number of pages | 6 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
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Keywords
- pharmaceutical capsules
- sodium alginate
- hypromellose
- gellan gum
- delayed release capsules
Cite this
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Polymer film formulations for the preparation of enteric pharmaceutical capsules. / Smith, Alan M.; Ingham, Andrew; Grover, Liam M.; Perrie, Yvonne.
In: Journal of Pharmacy and Pharmacology, Vol. 62, No. 2, 02.2010, p. 167-172.Research output: Contribution to journal › Article
TY - JOUR
T1 - Polymer film formulations for the preparation of enteric pharmaceutical capsules
AU - Smith, Alan M.
AU - Ingham, Andrew
AU - Grover, Liam M.
AU - Perrie, Yvonne
PY - 2010/2
Y1 - 2010/2
N2 - OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.
AB - OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.
KW - pharmaceutical capsules
KW - sodium alginate
KW - hypromellose
KW - gellan gum
KW - delayed release capsules
U2 - 10.1211/jpp.62.02.0003
DO - 10.1211/jpp.62.02.0003
M3 - Article
VL - 62
SP - 167
EP - 172
JO - Journal of Pharmacy and Pharmacology
T2 - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 2
ER -