Polymer film formulations for the preparation of enteric pharmaceutical capsules

Alan M. Smith, Andrew Ingham, Liam M. Grover, Yvonne Perrie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.

METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.

KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.

CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.

LanguageEnglish
Pages167-172
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Capsules
Polymers
Pharmaceutical Preparations
Stomach
Acids
Intestines
Polysaccharides
Gastrointestinal Tract
Phosphates
Equipment and Supplies
Water

Keywords

  • pharmaceutical capsules
  • sodium alginate
  • hypromellose
  • gellan gum
  • delayed release capsules

Cite this

Smith, Alan M. ; Ingham, Andrew ; Grover, Liam M. ; Perrie, Yvonne. / Polymer film formulations for the preparation of enteric pharmaceutical capsules. In: Journal of Pharmacy and Pharmacology. 2010 ; Vol. 62, No. 2. pp. 167-172.
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Polymer film formulations for the preparation of enteric pharmaceutical capsules. / Smith, Alan M.; Ingham, Andrew; Grover, Liam M.; Perrie, Yvonne.

In: Journal of Pharmacy and Pharmacology, Vol. 62, No. 2, 02.2010, p. 167-172.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymer film formulations for the preparation of enteric pharmaceutical capsules

AU - Smith, Alan M.

AU - Ingham, Andrew

AU - Grover, Liam M.

AU - Perrie, Yvonne

PY - 2010/2

Y1 - 2010/2

N2 - OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.

AB - OBJECTIVES: Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.METHODS: The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form capsules using standard industrial equipment.KEY FINDINGS: The rheological profile, on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mm HCl at pH 1.2, and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were ruptured.CONCLUSIONS: Selected formulations from this study have potential for use as delayed release capsules.

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