Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives

C. N. Grama, D. D. Ankola, M. N. V. R. Kumar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The benefits of increasing surface area to volume ratio have long been realized by the pharmaceutical industry for addressing the solubility limited oral bioavailability. In the recent past various excipients that include but not limited to polymers and lipids are used to engineer nanostructures that possess one or more of the following properties, improve oral bioavailability, improve therapeutic efficacy, sustain the release of the encapsulated bioactive, minimize toxicity, have the ability to target the pathological site of interest and also perform dual role of diagnosis and delivery of bioactives simultaneously. In this review, we attempt to discuss the use of poly(lactide-co-glycolide) (PLGA) nanoparticles in addressing the solubility/permeability limited bioavailability problems of various bioactives that include drugs as well as antioxidants.
Original languageEnglish
Pages (from-to)238-245
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Antioxidants
  • oral delivery
  • biodegradable nanoparticles
  • plga nanoparticles
  • encapsulated antioxidant nanoparticles
  • gastrointes
  • nanoparticles
  • polymeric nanoparticles
  • bioavailability
  • plga
  • behavior in-vitro
  • ellagic acid
  • biodegradable
  • drug-delivery
  • poly(lactide-co-glycolide) nanoparticles
  • peroral delivery
  • bioactives

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