Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives

C. N. Grama, D. D. Ankola, M. N. V. R. Kumar

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The benefits of increasing surface area to volume ratio have long been realized by the pharmaceutical industry for addressing the solubility limited oral bioavailability. In the recent past various excipients that include but not limited to polymers and lipids are used to engineer nanostructures that possess one or more of the following properties, improve oral bioavailability, improve therapeutic efficacy, sustain the release of the encapsulated bioactive, minimize toxicity, have the ability to target the pathological site of interest and also perform dual role of diagnosis and delivery of bioactives simultaneously. In this review, we attempt to discuss the use of poly(lactide-co-glycolide) (PLGA) nanoparticles in addressing the solubility/permeability limited bioavailability problems of various bioactives that include drugs as well as antioxidants.
LanguageEnglish
Pages238-245
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Polyglactin 910
bioavailability
activity (biology)
delivery
Nanoparticles
nanoparticles
solubility
Solubility
Excipients
antioxidants
Antioxidants
toxicity
Pharmaceutical Preparations
Drug products
Lipids
engineers
Toxicity
lipids
Nanostructures
permeability

Keywords

  • Antioxidants
  • oral delivery
  • biodegradable nanoparticles
  • plga nanoparticles
  • encapsulated antioxidant nanoparticles
  • gastrointes
  • nanoparticles
  • polymeric nanoparticles
  • bioavailability
  • plga
  • behavior in-vitro
  • ellagic acid
  • biodegradable
  • drug-delivery
  • poly(lactide-co-glycolide) nanoparticles
  • peroral delivery
  • bioactives

Cite this

Grama, C. N. ; Ankola, D. D. ; Kumar, M. N. V. R. / Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives. In: Current Opinion in Colloid and Interface Science . 2011 ; Vol. 16, No. 3. pp. 238-245.
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Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives. / Grama, C. N.; Ankola, D. D.; Kumar, M. N. V. R.

In: Current Opinion in Colloid and Interface Science , Vol. 16, No. 3, 06.2011, p. 238-245.

Research output: Contribution to journalArticle

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