Plasmonic detection of carbohydrate-mediated biological events

Isabel García, Jesús Mosquera, Javier Plou, Luis M. Liz-Marzán

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The incorporation of nanomaterials in glycoscience research enables the design of highly selective and sensitive bioanalytical devices for the detection of disease-associated biomarkers. In particular, localized surface plasmon resonance (LSPR) and surface enhanced Raman scattering (SERS) spectroscopies are powerful biosensing techniques that employ metallic nanostructures to achieve efficient detection of biomolecules. Herein, the most recent achievements are reviewed toward the use of plasmonic nanomaterials together with glycans or glycan-interacting moieties, to detect carbohydrate-mediated biological interactions. The review thus focuses on the use of novel optical nanosensors, mainly LSPR and SERS, for the detection of saccharides, lectins, viruses, bacteria, and even whole eukaryotic cells.

Original languageEnglish
Article number1800680
JournalAdvanced Optical Materials
Volume6
Issue number23
Early online date20 Aug 2018
DOIs
Publication statusPublished - 3 Dec 2018

Keywords

  • carbohydrates
  • glycan-mediated interactions
  • localized surface plasmon resonance
  • LSPR sensors
  • plasmonics
  • SERS sensors
  • surface enhanced Raman scattering

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