Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis

S.L. Jongbloed, R.A. Benson, M.B. Nickdel, P. Garside, L.B. McInnes, J.M. Brewer

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Achieving remission in rheumatoid arthritis (RA) remains elusive despite current biological therapeutics. Consequently, interest has increased in strategies to re-establish immune tolerance to provide long-term disease suppression. Although dendritic cells (DC) are prime candidates in initiating autoreactive T cell responses, and their presence within the synovial environment suggests a role in generation and maintenance of autoreactive, synovial T cell responses, their functional importance remains unclear. We investigated the contribution made by plasmacytoid DCs (pDCs) in the spontaneous breach of tolerance to arthritis-related self proteins, including rheumatoid factor, citrullinated peptide, and type II collagen observed in a novel arthritis model. Selective pDC depletion in vivo enhanced the severity of articular pathology and enhanced T and B cell autoimmune responses against type II collagen. pDC may offer a net anti-inflammatory function in the context of articular breach of tolerance. Such data will be vital in informing DC modulatory/therapeutic approaches.
LanguageEnglish
Pages963-968
Number of pages6
JournalJournal of Immunology
Volume182
Issue number2
Publication statusPublished - 15 Jan 2009

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Self Tolerance
Dendritic Cells
Arthritis
T-Lymphocytes
Joints
Immune Tolerance
Collagen Type II
Rheumatoid Factor
Autoimmunity
Rheumatoid Arthritis
B-Lymphocytes
Anti-Inflammatory Agents
Maintenance
Pathology
Peptides
Therapeutics

Keywords

  • plasmacytoid dendritic cells
  • autoimmune arthritis

Cite this

Jongbloed, S. L., Benson, R. A., Nickdel, M. B., Garside, P., McInnes, L. B., & Brewer, J. M. (2009). Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology, 182(2), 963-968.
Jongbloed, S.L. ; Benson, R.A. ; Nickdel, M.B. ; Garside, P. ; McInnes, L.B. ; Brewer, J.M. / Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. In: Journal of Immunology. 2009 ; Vol. 182, No. 2. pp. 963-968.
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Jongbloed, SL, Benson, RA, Nickdel, MB, Garside, P, McInnes, LB & Brewer, JM 2009, 'Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis' Journal of Immunology, vol. 182, no. 2, pp. 963-968.

Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. / Jongbloed, S.L.; Benson, R.A.; Nickdel, M.B.; Garside, P.; McInnes, L.B.; Brewer, J.M.

In: Journal of Immunology, Vol. 182, No. 2, 15.01.2009, p. 963-968.

Research output: Contribution to journalArticle

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Jongbloed SL, Benson RA, Nickdel MB, Garside P, McInnes LB, Brewer JM. Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology. 2009 Jan 15;182(2):963-968.