Abstract
The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel
murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.
Original language | English |
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Pages (from-to) | 102-102 |
Number of pages | 0 |
Journal | Immunology |
Volume | 125 |
Issue number | s1 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- plasmacytoid dendritic cells
- antigen presentation
- CD4+t cells
- immunology