The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.
- plasmacytoid dendritic cells
- antigen presentation
- CD4+t cells
Benson, R. A., Hutchison, S., Millington, O. R., McInnes, I. B., Garside, P., & Brewer, J. M. (2008). Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology, 125(s1), 102-102. https://doi.org/10.1111/j.1365-2567.2008.02974.x