Plasmacytoid dendritic cells and antigen presentation to CD4+t cells

R.A. Benson, S. Hutchison, O.R. Millington, I.B. McInnes, P. Garside, J.M. Brewer

Research output: Contribution to journalArticlepeer-review


The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.
Original languageEnglish
Pages (from-to)102-102
Number of pages0
Issue numbers1
Publication statusPublished - Dec 2008


  • plasmacytoid dendritic cells
  • antigen presentation
  • CD4+t cells
  • immunology


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