Plasmacytoid dendritic cells and antigen presentation to CD4+t cells

R.A. Benson, S. Hutchison, O.R. Millington, I.B. McInnes, P. Garside, J.M. Brewer

Research output: Contribution to journalArticle

Abstract

The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.
LanguageEnglish
Pages102-102
Number of pages0
JournalImmunology
Volume125
Issue numbers1
DOIs
Publication statusPublished - Dec 2008

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Antigen Presentation
Dendritic Cells
Pathology
T-Lymphocytes
Autoantibodies
Autoimmune Diseases
Rheumatoid Arthritis
Antigens

Keywords

  • plasmacytoid dendritic cells
  • antigen presentation
  • CD4+t cells
  • immunology

Cite this

Benson, R. A., Hutchison, S., Millington, O. R., McInnes, I. B., Garside, P., & Brewer, J. M. (2008). Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology, 125(s1), 102-102. https://doi.org/10.1111/j.1365-2567.2008.02974.x
Benson, R.A. ; Hutchison, S. ; Millington, O.R. ; McInnes, I.B. ; Garside, P. ; Brewer, J.M. / Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. In: Immunology. 2008 ; Vol. 125, No. s1. pp. 102-102.
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Benson, RA, Hutchison, S, Millington, OR, McInnes, IB, Garside, P & Brewer, JM 2008, 'Plasmacytoid dendritic cells and antigen presentation to CD4+t cells' Immunology, vol. 125, no. s1, pp. 102-102. https://doi.org/10.1111/j.1365-2567.2008.02974.x

Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. / Benson, R.A.; Hutchison, S.; Millington, O.R.; McInnes, I.B.; Garside, P.; Brewer, J.M.

In: Immunology, Vol. 125, No. s1, 12.2008, p. 102-102.

Research output: Contribution to journalArticle

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AU - Brewer, J.M.

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Benson RA, Hutchison S, Millington OR, McInnes IB, Garside P, Brewer JM. Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology. 2008 Dec;125(s1):102-102. https://doi.org/10.1111/j.1365-2567.2008.02974.x