Plant natural products in anti-diabetic drug discovery

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Plants and other natural sources have been useful in discovering drugs for treating patients with diabetes mellitus. Examples include the α-glucosidase inhibitor acarbose, and galegine, which contributed to the discovery and development of the biguanides. There are many traditionally used herbal medicines that lower blood glucose in experimental models, and, currently, there is considerable interest in exploring these plant extracts for compounds that might also be useful in the clinic or that might have novel effects, such as stimulation of β-cell proliferation. Often, neither their mechanism nor their active components have been defined, so it is possible that novel mechanisms of action and novel compounds will be discovered. In addition, there has been very little use of large collections of natural products in random screening campaigns against accepted therapeutic targets: there is great potential to find new chemical scaffolds for drugs with improved properties. This paper will provide an overview of recent activities relating to the use of natural products from plants as a source of compounds that might be beneficial in treating patients with diabetes.
Original languageEnglish
Pages (from-to)1670-1677
Number of pages7
JournalCurrent Organic Chemistry
Volume14
Issue number16
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Medical problems
Biological Products
Acarbose
Glucosidases
Biguanides
Plant Extracts
Cell proliferation
Scaffolds
Pharmaceutical Preparations
Blood Glucose
Screening
Drug Discovery
galegine

Keywords

  • plant natural products
  • diabetes mellitus
  • mechanistic studies
  • insulin
  • glucose absorption
  • lipid metabolism
  • inhibitor acarbose
  • galegine
  • a-glucosidase
  • herbal medicines
  • biguanides
  • b-cell proliferation
  • therapeutic targets
  • chemical scaffolds

Cite this

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abstract = "Plants and other natural sources have been useful in discovering drugs for treating patients with diabetes mellitus. Examples include the α-glucosidase inhibitor acarbose, and galegine, which contributed to the discovery and development of the biguanides. There are many traditionally used herbal medicines that lower blood glucose in experimental models, and, currently, there is considerable interest in exploring these plant extracts for compounds that might also be useful in the clinic or that might have novel effects, such as stimulation of β-cell proliferation. Often, neither their mechanism nor their active components have been defined, so it is possible that novel mechanisms of action and novel compounds will be discovered. In addition, there has been very little use of large collections of natural products in random screening campaigns against accepted therapeutic targets: there is great potential to find new chemical scaffolds for drugs with improved properties. This paper will provide an overview of recent activities relating to the use of natural products from plants as a source of compounds that might be beneficial in treating patients with diabetes.",
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Plant natural products in anti-diabetic drug discovery. / Harvey, A.L.

In: Current Organic Chemistry, Vol. 14, No. 16, 10.2010, p. 1670-1677.

Research output: Contribution to journalArticle

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