Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

Manjuan Liu; David R. Katerere; Alexander I. Gray; Veronique Seidel

doi:10.1016/j.fitote.2009.05.006

Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

Manjuan Liu, David R. Katerere, Alexander I. Gray, Veronique Seidel

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.

Original language	English
Pages (from-to)	369-373
Number of pages	4
Journal	Fitoterapia
Volume	80
Issue number	6
Early online date	14 May 2009
DOIs	https://doi.org/10.1016/j.fitote.2009.05.006
Publication status	Published - 1 Sept 2009

Keywords

terminalia mollis
terminalia brachystemma
combretaceae
punicalagin
antifungal activity

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10.1016/j.fitote.2009.05.006

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title = "Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma",

abstract = "Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.",

keywords = "terminalia mollis, terminalia brachystemma, combretaceae, punicalagin, antifungal activity",

author = "Manjuan Liu and Katerere, {David R.} and Gray, {Alexander I.} and Veronique Seidel",

year = "2009",

month = sep,

day = "1",

doi = "10.1016/j.fitote.2009.05.006",

language = "English",

volume = "80",

pages = "369--373",

journal = "Fitoterapia",

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T1 - Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

AU - Liu, Manjuan

AU - Katerere, David R.

AU - Gray, Alexander I.

AU - Seidel, Veronique

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.

AB - Phytochemical investigation of the stem bark of Terminalia mollis afforded friedelin (1), catechin with epicatechin (2), gallocatechin with epigallocatechin (3) and 3-O-methylellagic acid 4'-O-alpha-rhamnopyranoside (4). Arjunolic acid with 2 alpha, 3 beta, 23-trihydroxy-urs-12-en-28-oic acid (5), 2 alpha-hydroxyursolic acid (6), gallic acid (7), chebulanin (8) and 2 ''-O-galloylvitexin (9) were isolated from the leaf. Chebulanin (8), betulinic acid (10), ursolic acid (11), catechin (12), isoorientin (13), orientin (14), isovitexin (15) and punicalagin (16) were isolated from Terminalia brachystemma leaf The first full unambiguous NMR assignments for (4) and (8), and revised assignments for (9), are reported. Compound (16) showed good activity against three Candida species.

KW - terminalia mollis

KW - terminalia brachystemma

KW - combretaceae

KW - punicalagin

KW - antifungal activity

UR - http://www.sciencedirect.com/science/article/pii/S0367326X09001038

U2 - 10.1016/j.fitote.2009.05.006

DO - 10.1016/j.fitote.2009.05.006

M3 - Article

SN - 0367-326X

VL - 80

SP - 369

EP - 373

JO - Fitoterapia

JF - Fitoterapia

IS - 6

ER -

Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma

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Keywords

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