Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents

Jakob Tarp, Abbey Child, Tom White, Kate Westgate, Anna Bugge, Anders Grøntved, Niels Wedderkopp, Lars B. Andersen, Greet Cardon, Rachel Davey, Kathleen F Janz, Susi Kriemler, Kate Northstone, Angie S. Page, Jardena J. Puder, John J. Reilly, Luis B. Sardinha, Esther M. F. van Sluijs, Ulf Ekelund, Katrien Wijndaele & 2 others Søren Brage, On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4–18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. Results: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a −0.027 (95% CI: −0.039 to −0.014) standard deviations lower composite risk score, and a −0.064 (95% CI: −0.09 to −0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: −0.002 (95% CI: −0.005 to 0.0005) standard deviations for the composite risk score, and −0.005 (95% CI: −0.012 to 0.002) kg/m2 for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.

LanguageEnglish
Number of pages12
JournalInternational Journal of Obesity
DOIs
Publication statusPublished - 13 Jul 2018

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Exercise
Accelerometry
Linear Models
Adiposity
Waist Circumference
Body Mass Index
Cross-Sectional Studies
Biomarkers
Databases
Blood Pressure

Keywords

  • physical activity
  • children
  • adolescents

Cite this

Tarp, J., Child, A., White, T., Westgate, K., Bugge, A., Grøntved, A., ... On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators (2018). Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents. International Journal of Obesity. https://doi.org/10.1038/s41366-018-0152-8
Tarp, Jakob ; Child, Abbey ; White, Tom ; Westgate, Kate ; Bugge, Anna ; Grøntved, Anders ; Wedderkopp, Niels ; Andersen, Lars B. ; Cardon, Greet ; Davey, Rachel ; Janz, Kathleen F ; Kriemler, Susi ; Northstone, Kate ; Page, Angie S. ; Puder, Jardena J. ; Reilly, John J. ; Sardinha, Luis B. ; van Sluijs, Esther M. F. ; Ekelund, Ulf ; Wijndaele, Katrien ; Brage, Søren ; On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators. / Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents. In: International Journal of Obesity. 2018.
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abstract = "Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4–18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. Results: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a −0.027 (95{\%} CI: −0.039 to −0.014) standard deviations lower composite risk score, and a −0.064 (95{\%} CI: −0.09 to −0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: −0.002 (95{\%} CI: −0.005 to 0.0005) standard deviations for the composite risk score, and −0.005 (95{\%} CI: −0.012 to 0.002) kg/m2 for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.",
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author = "Jakob Tarp and Abbey Child and Tom White and Kate Westgate and Anna Bugge and Anders Gr{\o}ntved and Niels Wedderkopp and Andersen, {Lars B.} and Greet Cardon and Rachel Davey and Janz, {Kathleen F} and Susi Kriemler and Kate Northstone and Page, {Angie S.} and Puder, {Jardena J.} and Reilly, {John J.} and Sardinha, {Luis B.} and {van Sluijs}, {Esther M. F.} and Ulf Ekelund and Katrien Wijndaele and S{\o}ren Brage and {On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators}",
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Tarp, J, Child, A, White, T, Westgate, K, Bugge, A, Grøntved, A, Wedderkopp, N, Andersen, LB, Cardon, G, Davey, R, Janz, KF, Kriemler, S, Northstone, K, Page, AS, Puder, JJ, Reilly, JJ, Sardinha, LB, van Sluijs, EMF, Ekelund, U, Wijndaele, K, Brage, S & On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators 2018, 'Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents' International Journal of Obesity. https://doi.org/10.1038/s41366-018-0152-8

Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents. / Tarp, Jakob; Child, Abbey; White, Tom; Westgate, Kate; Bugge, Anna; Grøntved, Anders; Wedderkopp, Niels; Andersen, Lars B.; Cardon, Greet; Davey, Rachel; Janz, Kathleen F; Kriemler, Susi; Northstone, Kate; Page, Angie S.; Puder, Jardena J.; Reilly, John J.; Sardinha, Luis B.; van Sluijs, Esther M. F.; Ekelund, Ulf; Wijndaele, Katrien; Brage, Søren; On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators.

In: International Journal of Obesity, 13.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents

AU - Tarp, Jakob

AU - Child, Abbey

AU - White, Tom

AU - Westgate, Kate

AU - Bugge, Anna

AU - Grøntved, Anders

AU - Wedderkopp, Niels

AU - Andersen, Lars B.

AU - Cardon, Greet

AU - Davey, Rachel

AU - Janz, Kathleen F

AU - Kriemler, Susi

AU - Northstone, Kate

AU - Page, Angie S.

AU - Puder, Jardena J.

AU - Reilly, John J.

AU - Sardinha, Luis B.

AU - van Sluijs, Esther M. F.

AU - Ekelund, Ulf

AU - Wijndaele, Katrien

AU - Brage, Søren

AU - On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators

PY - 2018/7/13

Y1 - 2018/7/13

N2 - Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4–18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. Results: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a −0.027 (95% CI: −0.039 to −0.014) standard deviations lower composite risk score, and a −0.064 (95% CI: −0.09 to −0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: −0.002 (95% CI: −0.005 to 0.0005) standard deviations for the composite risk score, and −0.005 (95% CI: −0.012 to 0.002) kg/m2 for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.

AB - Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4–18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. Results: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a −0.027 (95% CI: −0.039 to −0.014) standard deviations lower composite risk score, and a −0.064 (95% CI: −0.09 to −0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: −0.002 (95% CI: −0.005 to 0.0005) standard deviations for the composite risk score, and −0.005 (95% CI: −0.012 to 0.002) kg/m2 for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.

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KW - children

KW - adolescents

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