Photovoltaic retinal prosthesis with high pixel density

Keith Mathieson, James Loudin, Georges Goetz, Philip Huie, Lele Wang, Theodore I. Kamins, Ludwig Galambos, Richard Smith, James S. Harris, Alexander Sher, Daniel Palanker

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Retinal degenerative diseases lead to blindness due to loss of the ‘image capturing’ photoreceptors, while neurons in the ‘image-processing’ inner retinal layers are relatively well preserved. Electronic retinal prostheses seek to restore sight by electrically stimulating the surviving neurons. Most implants are powered through inductive coils, requiring complex surgical methods to implant the coil-decoder-cable-array systems that deliver energy to stimulating electrodes via intraocular cables. We present a photovoltaic subretinal prosthesis, in which silicon photodiodes in each pixel receive power and data directly through pulsed near-infrared illumination and electrically stimulate neurons. Stimulation is produced in normal and degenerate rat retinas, with pulse durations of 0.5–4 ms, and threshold peak irradiances of 0.2–10 mW mm−2, two orders of magnitude below the ocular safety limit. Neural responses were elicited by illuminating a single 70 µm bipolar pixel, demonstrating the possibility of a fully integrated photovoltaic retinal prosthesis with high pixel density.
LanguageEnglish
Pages391-397
Number of pages7
JournalNature Photonics
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 2012

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neurons
Neurons
Pixels
pixels
cables
Cables
coils
blindness
photoreceptors
retina
decoders
visual perception
Silicon
Prosthetics
Photodiodes
stimulation
irradiance
illuminating
rats
photodiodes

Keywords

  • biophotonics
  • solar energy
  • photovoltaic technology

Cite this

Mathieson, K., Loudin, J., Goetz, G., Huie, P., Wang, L., Kamins, T. I., ... Palanker, D. (2012). Photovoltaic retinal prosthesis with high pixel density. Nature Photonics, 6(6), 391-397. https://doi.org/10.1038/nphoton.2012.104
Mathieson, Keith ; Loudin, James ; Goetz, Georges ; Huie, Philip ; Wang, Lele ; Kamins, Theodore I. ; Galambos, Ludwig ; Smith, Richard ; Harris, James S. ; Sher, Alexander ; Palanker, Daniel. / Photovoltaic retinal prosthesis with high pixel density. In: Nature Photonics. 2012 ; Vol. 6, No. 6. pp. 391-397.
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Mathieson, K, Loudin, J, Goetz, G, Huie, P, Wang, L, Kamins, TI, Galambos, L, Smith, R, Harris, JS, Sher, A & Palanker, D 2012, 'Photovoltaic retinal prosthesis with high pixel density' Nature Photonics, vol. 6, no. 6, pp. 391-397. https://doi.org/10.1038/nphoton.2012.104

Photovoltaic retinal prosthesis with high pixel density. / Mathieson, Keith; Loudin, James; Goetz, Georges; Huie, Philip; Wang, Lele; Kamins, Theodore I.; Galambos, Ludwig; Smith, Richard; Harris, James S.; Sher, Alexander; Palanker, Daniel.

In: Nature Photonics, Vol. 6, No. 6, 06.2012, p. 391-397.

Research output: Contribution to journalArticle

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