Photovoltaic restoration of sight with high visual acuity

Henri Lorach, Georges Goetz, Richard Smith, Xin Lei, Yossi Mandel, Theodore Kamins, Keith Mathieson, Philip Huie, James Harris, Alexander Sher, Daniel Palanker

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Patients with retinal degeneration lose sight due to the gradual demise of photoreceptors. Electrical stimulation of surviving retinal neurons provides an alternative route for the delivery of visual information. We demonstrate that subretinal implants with 70-μm-wide photovoltaic pixels provide highly localized stimulation of retinal neurons in rats. The electrical receptive fields recorded in retinal ganglion cells were similar in size to the natural visual receptive fields. Similarly to normal vision, the retinal response to prosthetic stimulation exhibited flicker fusion at high frequencies, adaptation to static images and nonlinear spatial summation. In rats with retinal degeneration, these photovoltaic arrays elicited retinal responses with a spatial resolution of 64 ± 11 μm, corresponding to half of the normal visual acuity in healthy rats. The ease of implantation of these wireless and modular arrays, combined with their high resolution, opens the door to the functional restoration of sight in patients blinded by retinal degeneration.

LanguageEnglish
JournalNature Medicine
Early online date27 Apr 2015
DOIs
Publication statusPublished - 2015

Fingerprint

Retinal Degeneration
Visual Acuity
Restoration
Retinal Neurons
Rats
Neurons
Flicker Fusion
Retinal Ganglion Cells
Prosthetics
Visual Fields
Electric Stimulation
Fusion reactions
Pixels

Keywords

  • retinal degeneration
  • sight loss
  • sight measurement
  • retinal ganglion cells
  • subretinal implants

Cite this

Lorach, Henri ; Goetz, Georges ; Smith, Richard ; Lei, Xin ; Mandel, Yossi ; Kamins, Theodore ; Mathieson, Keith ; Huie, Philip ; Harris, James ; Sher, Alexander ; Palanker, Daniel. / Photovoltaic restoration of sight with high visual acuity. In: Nature Medicine. 2015.
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Lorach, H, Goetz, G, Smith, R, Lei, X, Mandel, Y, Kamins, T, Mathieson, K, Huie, P, Harris, J, Sher, A & Palanker, D 2015, 'Photovoltaic restoration of sight with high visual acuity' Nature Medicine. https://doi.org/10.1038/nm.3851

Photovoltaic restoration of sight with high visual acuity. / Lorach, Henri; Goetz, Georges; Smith, Richard; Lei, Xin; Mandel, Yossi; Kamins, Theodore; Mathieson, Keith; Huie, Philip; Harris, James; Sher, Alexander; Palanker, Daniel.

In: Nature Medicine, 2015.

Research output: Contribution to journalArticle

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Lorach H, Goetz G, Smith R, Lei X, Mandel Y, Kamins T et al. Photovoltaic restoration of sight with high visual acuity. Nature Medicine. 2015. https://doi.org/10.1038/nm.3851