Photovoltaic restoration of high visual acuity in rats with retinal degeneration

H. Lorach, G. Goetz, Y. Mandel, R. Smith, D. Boinagrov, X. Lei, R. Dalal, P. Huie, T. Kamins, J. Harris, K. Mathieson, A. Sher, D. Palanker

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.

Original languageEnglish
Title of host publicationInternational IEEE/EMBS Conference on Neural Engineering, NER
Pages248-251
Number of pages4
DOIs
Publication statusPublished - 1 Jul 2015
Event7th International IEEE/EMBS Conference on Neural Engineering, NER 2015 - Montpellier, France
Duration: 22 Apr 201524 Apr 2015

Conference

Conference7th International IEEE/EMBS Conference on Neural Engineering, NER 2015
CountryFrance
CityMontpellier
Period22/04/1524/04/15

Keywords

  • bioelectric phenomena
  • biomedical optical imaging
  • eye
  • image resolution
  • medical image processing
  • optical tomography
  • prosthetics
  • vision

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  • Cite this

    Lorach, H., Goetz, G., Mandel, Y., Smith, R., Boinagrov, D., Lei, X., ... Palanker, D. (2015). Photovoltaic restoration of high visual acuity in rats with retinal degeneration. In International IEEE/EMBS Conference on Neural Engineering, NER (pp. 248-251) https://doi.org/10.1109/NER.2015.7146606