Photoluminescent nanosensors for intracellular detection

Roberto De La Rica, Caitlin Kerr

Research output: Contribution to journalLiterature review

10 Citations (Scopus)

Abstract

In this manuscript we review the main strategies for detecting changes in intracellular parameters with photoluminescent nanosensors. Examples of the detection of intracellular pH, ion concentration (Na+, Ca2+, Zn2+, Hg2+), reactive oxygen species (ROS, e.g. hydrogen peroxide), variations in temperature, changes in RNA levels and the detection of enzymatic activity are described in detail. The utilisation of nanomaterials such as quantum dots, silicon carbide nanoparticles, nanoscale metal-organic frameworks, upconverting nanoparticles, fluorescent nanoclusters, gold nanoparticles, nanodiamonds, dendrimers and polymeric nanoparticles in bioimaging is highlighted. When compared to molecular probes, nanosensors combine high sensitivity and selectivity with low toxicity, which are crucial parameters for sensing in live cells.
LanguageEnglish
JournalAnalytical Methods
Early online date2 Apr 2015
DOIs
Publication statusPublished - 2015

Fingerprint

Nanosensors
Nanoparticles
Nanodiamonds
Dendrimers
Molecular Probes
Metal nanoparticles
Nanoclusters
RNA
Nanostructured materials
Hydrogen peroxide
Silicon carbide
Gold
Hydrogen Peroxide
Semiconductor quantum dots
Toxicity
Reactive Oxygen Species
Ions
Oxygen
Temperature

Keywords

  • photoluminescence
  • nanosensors
  • bioimaging

Cite this

De La Rica, Roberto ; Kerr, Caitlin. / Photoluminescent nanosensors for intracellular detection. In: Analytical Methods. 2015.
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author = "{De La Rica}, Roberto and Caitlin Kerr",
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Photoluminescent nanosensors for intracellular detection. / De La Rica, Roberto; Kerr, Caitlin.

In: Analytical Methods, 2015.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Photoluminescent nanosensors for intracellular detection

AU - De La Rica, Roberto

AU - Kerr, Caitlin

PY - 2015

Y1 - 2015

N2 - In this manuscript we review the main strategies for detecting changes in intracellular parameters with photoluminescent nanosensors. Examples of the detection of intracellular pH, ion concentration (Na+, Ca2+, Zn2+, Hg2+), reactive oxygen species (ROS, e.g. hydrogen peroxide), variations in temperature, changes in RNA levels and the detection of enzymatic activity are described in detail. The utilisation of nanomaterials such as quantum dots, silicon carbide nanoparticles, nanoscale metal-organic frameworks, upconverting nanoparticles, fluorescent nanoclusters, gold nanoparticles, nanodiamonds, dendrimers and polymeric nanoparticles in bioimaging is highlighted. When compared to molecular probes, nanosensors combine high sensitivity and selectivity with low toxicity, which are crucial parameters for sensing in live cells.

AB - In this manuscript we review the main strategies for detecting changes in intracellular parameters with photoluminescent nanosensors. Examples of the detection of intracellular pH, ion concentration (Na+, Ca2+, Zn2+, Hg2+), reactive oxygen species (ROS, e.g. hydrogen peroxide), variations in temperature, changes in RNA levels and the detection of enzymatic activity are described in detail. The utilisation of nanomaterials such as quantum dots, silicon carbide nanoparticles, nanoscale metal-organic frameworks, upconverting nanoparticles, fluorescent nanoclusters, gold nanoparticles, nanodiamonds, dendrimers and polymeric nanoparticles in bioimaging is highlighted. When compared to molecular probes, nanosensors combine high sensitivity and selectivity with low toxicity, which are crucial parameters for sensing in live cells.

KW - photoluminescence

KW - nanosensors

KW - bioimaging

U2 - 10.1039/C5AY00489F

DO - 10.1039/C5AY00489F

M3 - Literature review

JO - Analytical Methods

T2 - Analytical Methods

JF - Analytical Methods

SN - 1759-9660

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