Photoactivated release of membrane impermeant sulfonates inside cells

Stuart T. Caldwell; Sean N. O’Byrne; Calum Wilson; Filip Cvetko; Michael P. Murphy; John G. McCarron; Richard C. Hartley

doi:10.1039/D0CC07713E

Photoactivated release of membrane impermeant sulfonates inside cells

Stuart T. Caldwell, Sean N. O’Byrne, Calum Wilson, Filip Cvetko, Michael P. Murphy, John G. McCarron, Richard C. Hartley

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

5 Downloads (Pure)

Abstract

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane
impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

Original language	English
Pages (from-to)	3917-3920
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	32
Early online date	12 Mar 2021
DOIs	https://doi.org/10.1039/D0CC07713E
Publication status	Published - 25 Apr 2021

Keywords

photouncaging
photochemical trapping
caging

Access to Document

10.1039/D0CC07713ELicence: CC BY 3.0

Caldwell-etal-CC-2021-Photoactivated-release-of-membrane-impermeant-sulfonates-insideFinal published version, 2.45 MBLicence: CC BY 3.0

Cite this

@article{50c3c7280dc54f67a6501027520b4711,

title = "Photoactivated release of membrane impermeant sulfonates inside cells",

abstract = "Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membraneimpermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.",

keywords = "photouncaging, photochemical trapping, caging",

author = "Caldwell, {Stuart T.} and O{\textquoteright}Byrne, {Sean N.} and Calum Wilson and Filip Cvetko and Murphy, {Michael P.} and McCarron, {John G.} and Hartley, {Richard C.}",

year = "2021",

month = apr,

day = "25",

doi = "10.1039/D0CC07713E",

language = "English",

volume = "57",

pages = "3917--3920",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "32",

}

TY - JOUR

T1 - Photoactivated release of membrane impermeant sulfonates inside cells

AU - Caldwell, Stuart T.

AU - O’Byrne, Sean N.

AU - Wilson, Calum

AU - Cvetko, Filip

AU - Murphy, Michael P.

AU - McCarron, John G.

AU - Hartley, Richard C.

PY - 2021/4/25

Y1 - 2021/4/25

N2 - Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membraneimpermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

AB - Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membraneimpermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

KW - photouncaging

KW - photochemical trapping

KW - caging

UR - http://pubs.rsc.org/en/Journals/JournalIssues/CC

U2 - 10.1039/D0CC07713E

DO - 10.1039/D0CC07713E

M3 - Article

SN - 1359-7345

VL - 57

SP - 3917

EP - 3920

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

Photoactivated release of membrane impermeant sulfonates inside cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Optical dissection of endothelial calcium signalling Sir Henry Wellcome Postdoctoral Fellowship

Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within

Cite this

Photoactivated release of membrane impermeant sulfonates inside cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

Optical dissection of endothelial calcium signalling Sir Henry Wellcome Postdoctoral Fellowship

Optical Cannula: Development of a tool for studying the inside of tubular organs under physiologically relevant conditions by imaging from within

Cite this