Photoactivated release of membrane impermeant sulfonates inside cells

Stuart T. Caldwell, Sean N. O’Byrne, Calum Wilson, Filip Cvetko, Michael P. Murphy, John G. McCarron, Richard C. Hartley

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
5 Downloads (Pure)


Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane
impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.
Original languageEnglish
Pages (from-to)3917-3920
Number of pages4
JournalChemical Communications
Issue number32
Early online date12 Mar 2021
Publication statusPublished - 25 Apr 2021


  • photouncaging
  • photochemical trapping
  • caging


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