Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein

Yanna C. F. Teles; Jaime Ribeiro-Filho; Patrícia T. Bozza; Maria de Fátima Agra; Weam Siheri; John O. Igoli; Alexander I. Gray; Maria de Fátima V. de Souza

doi:10.1080/14786419.2015.1081196

Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein

Yanna C. F. Teles, Jaime Ribeiro-Filho, Patrícia T. Bozza, Maria de Fátima Agra, Weam Siheri, John O. Igoli, Alexander I. Gray, Maria de Fátima V. de Souza

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.

Original language	English
Pages (from-to)	1880-1884
Number of pages	5
Journal	Natural Product Research
Volume	30
Issue number	16
Early online date	11 Sept 2015
DOIs	https://doi.org/10.1080/14786419.2015.1081196
Publication status	Published - 2016

Keywords

7,4′-di-O-methylisoscutellarein
anti-inflammatory activity
Malvaceae
Wissadula periplocifolia

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10.1080/14786419.2015.1081196

https://www.arca.fiocruz.br/handle/icict/40928

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title = "Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein",

abstract = "This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.",

keywords = "7,4′-di-O-methylisoscutellarein, anti-inflammatory activity, Malvaceae, Wissadula periplocifolia",

author = "Teles, {Yanna C. F.} and Jaime Ribeiro-Filho and Bozza, {Patr{\'i}cia T.} and Agra, {Maria de F{\'a}tima} and Weam Siheri and Igoli, {John O.} and Gray, {Alexander I.} and Souza, {Maria de F{\'a}tima V. de}",

year = "2016",

doi = "10.1080/14786419.2015.1081196",

language = "English",

volume = "30",

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AU - Teles, Yanna C. F.

AU - Ribeiro-Filho, Jaime

AU - Bozza, Patrícia T.

AU - Agra, Maria de Fátima

AU - Siheri, Weam

AU - Igoli, John O.

AU - Gray, Alexander I.

AU - Souza, Maria de Fátima V. de

PY - 2016

Y1 - 2016

N2 - This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.

AB - This study reports the first phenolics from Wissadula genus (Malvaceae) and the anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein. Using chromatographic methods, five phenolic compounds were isolated from aerial parts of Wissadula periplocifolia (L.) C. Presl. The compounds were identified as 4-hydroxybenzoic acid, 3-hydroxybenzoic acid, trans-cinnamic acid, tamgermanetin and 7,4'-di-O-methylisoscutellarein using spectroscopic methods. The flavone 7,4'-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1β and TNF-α.

KW - 7,4′-di-O-methylisoscutellarein

KW - anti-inflammatory activity

KW - Malvaceae

KW - Wissadula periplocifolia

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IS - 16

ER -

Phenolic constituents from Wissadula periplocifolia (L.) C. Presl. and anti-inflammatory activity of 7,4'-di-O-methylisoscutellarein

Abstract

Keywords

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