Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor

Susannah J Stanway, Atul Purohit, L W Lawrence Woo, Saulat Sufi, David Vigushin, Rebecca Ward, Richard H Wilson, Frank Z Stanczyk, Nicola Dobbs, Elena Kulinskaya, Moira Elliott, Barry V L Potter, Michael J Reed, R Charles Coombes

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties.
Original languageEnglish
Pages (from-to)1585-92
Number of pages8
JournalClinical Cancer Research
Volume12
Issue number5
DOIs
Publication statusPublished - 2006

Fingerprint

Steryl-Sulfatase
Androstenediol
Steroids
Breast Neoplasms
Estrone
Sulfates
Estradiol
Hydrolysis
Hormones
Enzymes
irosustat
Therapeutics

Keywords

  • androstenediol
  • breast neoplasms
  • coumarins
  • estradiol
  • estrone
  • neoplasm metastasis
  • neoplasms
  • sulfonamides
  • testosterone

Cite this

Stanway, S. J., Purohit, A., Woo, L. W. L., Sufi, S., Vigushin, D., Ward, R., ... Coombes, R. C. (2006). Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical Cancer Research, 12(5), 1585-92. https://doi.org/10.1158/1078-0432.CCR-05-1996
Stanway, Susannah J ; Purohit, Atul ; Woo, L W Lawrence ; Sufi, Saulat ; Vigushin, David ; Ward, Rebecca ; Wilson, Richard H ; Stanczyk, Frank Z ; Dobbs, Nicola ; Kulinskaya, Elena ; Elliott, Moira ; Potter, Barry V L ; Reed, Michael J ; Coombes, R Charles. / Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. In: Clinical Cancer Research. 2006 ; Vol. 12, No. 5. pp. 1585-92.
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Stanway, SJ, Purohit, A, Woo, LWL, Sufi, S, Vigushin, D, Ward, R, Wilson, RH, Stanczyk, FZ, Dobbs, N, Kulinskaya, E, Elliott, M, Potter, BVL, Reed, MJ & Coombes, RC 2006, 'Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor', Clinical Cancer Research, vol. 12, no. 5, pp. 1585-92. https://doi.org/10.1158/1078-0432.CCR-05-1996

Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. / Stanway, Susannah J; Purohit, Atul; Woo, L W Lawrence; Sufi, Saulat; Vigushin, David; Ward, Rebecca; Wilson, Richard H; Stanczyk, Frank Z; Dobbs, Nicola; Kulinskaya, Elena; Elliott, Moira; Potter, Barry V L; Reed, Michael J; Coombes, R Charles.

In: Clinical Cancer Research, Vol. 12, No. 5, 2006, p. 1585-92.

Research output: Contribution to journalArticle

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AU - Purohit, Atul

AU - Woo, L W Lawrence

AU - Sufi, Saulat

AU - Vigushin, David

AU - Ward, Rebecca

AU - Wilson, Richard H

AU - Stanczyk, Frank Z

AU - Dobbs, Nicola

AU - Kulinskaya, Elena

AU - Elliott, Moira

AU - Potter, Barry V L

AU - Reed, Michael J

AU - Coombes, R Charles

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KW - androstenediol

KW - breast neoplasms

KW - coumarins

KW - estradiol

KW - estrone

KW - neoplasm metastasis

KW - neoplasms

KW - sulfonamides

KW - testosterone

U2 - 10.1158/1078-0432.CCR-05-1996

DO - 10.1158/1078-0432.CCR-05-1996

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