Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Huaiyu Yang; Åke C. Rasmuson

doi:10.1016/j.fluid.2014.11.007

Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Huaiyu Yang^*, Åke C. Rasmuson

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The influence of liquid-liquid phase separation (LLPS) in a crystallizing system is examined, and the liquid-liquid tie lines are determined in the ternary system of butyl paraben, water and ethanol. Crystallization by evaporation in droplets (solution of butyl paraben in ethanol and water mixtures) of homogeneous solution and two-phase liquid mixtures on plates of different materials: glass, plastic, steel, and tin were investigated by microscopy. Different crystallization and liquid-liquid phase separation behaviour are observed depending on initial droplet composition and the surface material. This work reveals that crystallization in the LLPS solution of butyl paraben in ethanol-water mixtures starts in the butyl paraben rich phase as can be explained by a higher butyl paraben concentration, and a lower solid-liquid interfacial energy.

Original language	English
Pages (from-to)	120-128
Number of pages	9
Journal	Fluid Phase Equilibria
Volume	385
Early online date	7 Nov 2014
DOIs	https://doi.org/10.1016/j.fluid.2014.11.007
Publication status	Published - 15 Jan 2015

Keywords

butyl paraben
ethanol and water
evaporation crystallization
liquid-liquid phase separation
nucleation

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10.1016/j.fluid.2014.11.007

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abstract = "The influence of liquid-liquid phase separation (LLPS) in a crystallizing system is examined, and the liquid-liquid tie lines are determined in the ternary system of butyl paraben, water and ethanol. Crystallization by evaporation in droplets (solution of butyl paraben in ethanol and water mixtures) of homogeneous solution and two-phase liquid mixtures on plates of different materials: glass, plastic, steel, and tin were investigated by microscopy. Different crystallization and liquid-liquid phase separation behaviour are observed depending on initial droplet composition and the surface material. This work reveals that crystallization in the LLPS solution of butyl paraben in ethanol-water mixtures starts in the butyl paraben rich phase as can be explained by a higher butyl paraben concentration, and a lower solid-liquid interfacial energy.",

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T1 - Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

AU - Yang, Huaiyu

AU - Rasmuson, Åke C.

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The influence of liquid-liquid phase separation (LLPS) in a crystallizing system is examined, and the liquid-liquid tie lines are determined in the ternary system of butyl paraben, water and ethanol. Crystallization by evaporation in droplets (solution of butyl paraben in ethanol and water mixtures) of homogeneous solution and two-phase liquid mixtures on plates of different materials: glass, plastic, steel, and tin were investigated by microscopy. Different crystallization and liquid-liquid phase separation behaviour are observed depending on initial droplet composition and the surface material. This work reveals that crystallization in the LLPS solution of butyl paraben in ethanol-water mixtures starts in the butyl paraben rich phase as can be explained by a higher butyl paraben concentration, and a lower solid-liquid interfacial energy.

AB - The influence of liquid-liquid phase separation (LLPS) in a crystallizing system is examined, and the liquid-liquid tie lines are determined in the ternary system of butyl paraben, water and ethanol. Crystallization by evaporation in droplets (solution of butyl paraben in ethanol and water mixtures) of homogeneous solution and two-phase liquid mixtures on plates of different materials: glass, plastic, steel, and tin were investigated by microscopy. Different crystallization and liquid-liquid phase separation behaviour are observed depending on initial droplet composition and the surface material. This work reveals that crystallization in the LLPS solution of butyl paraben in ethanol-water mixtures starts in the butyl paraben rich phase as can be explained by a higher butyl paraben concentration, and a lower solid-liquid interfacial energy.

KW - butyl paraben

KW - ethanol and water

KW - evaporation crystallization

KW - liquid-liquid phase separation

KW - nucleation

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U2 - 10.1016/j.fluid.2014.11.007

DO - 10.1016/j.fluid.2014.11.007

M3 - Article

AN - SCOPUS:84909644076

SN - 0378-3812

VL - 385

SP - 120

EP - 128

JO - Fluid Phase Equilibria

JF - Fluid Phase Equilibria

ER -

Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

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CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

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Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Abstract

Keywords

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CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

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