Projects per year
Abstract
The development of an antisolvent crystallization process requires the construction of an accurate phase diagram for this ternary system of compound, solvent and antisolvent, preferably as a function of temperature. This study gives an efficient methodology to systematically determine such antisolvent phase diagrams, exemplified with four model compounds: Sodium bromate, DL-Asparagine Monohydrate, Mefenamic acid and Lovastatin. Using clear point temperature measurements, single solvent and mixed solvent-antisolvent solubilities are obtained, showing strongly non-linear solubility dependencies as well as more complex solubility behaviour as a function of antisolvent fraction. A semi-empirical model equation is used to describe the phase diagram of the antisolvent crystallization system as a function of both temperature and antisolvent fraction. The phase diagram model then allows for the identification of condition ranges for optimal productivity, yield, and suspension density in continuous antisolvent crystallization processes.
Original language | English |
---|---|
Article number | 1102 |
Number of pages | 15 |
Journal | Crystals |
Volume | 12 |
Issue number | 8 |
Early online date | 6 Aug 2022 |
DOIs | |
Publication status | Published - 6 Aug 2022 |
Keywords
- solubility in mixed solvents
- antisolvent crystallization
- continuous crystallization
- crystallization process development
Fingerprint
Dive into the research topics of 'Phase diagram determination and process development for continuous antisolvent crystallizations'. Together they form a unique fingerprint.Projects
- 2 Finished
-
CORE - Continuous Resolution and Deracemization of Chiral Compounds by Crystallization MSCA ETN
Ter Horst, J. (Principal Investigator)
European Commission - Horizon Europe + H2020
1/10/16 → 30/09/20
Project: Research
-
CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Florence, A. (Principal Investigator), Bititci, U. (Co-investigator), Halbert, G. (Co-investigator), Littlejohn, D. (Co-investigator) & Sefcik, J. (Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/11 → 31/12/16
Project: Research