Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade

G. Marshall; A.C. Rankin; K.A. Kane; A.J. Workman

doi:10.1093/eurheartj/ehl212

Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade

G. Marshall, A.C. Rankin, K.A. Kane, A.J. Workman

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.

Original language	English
Article number	389
Pages (from-to)	30-30
Number of pages	1
Journal	European Heart Journal
Volume	27
Issue number	Supplement 1
DOIs	https://doi.org/10.1093/eurheartj/ehl212
Publication status	Published - Aug 2006
Event	World Congress of Cardiology 2006 - Barcelona, Spain Duration: 2 Sept 2006 → 6 Sept 2006

Keywords

beta blocker
pharmacology
human atrial K+ currents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/eurheartj/ehl212

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title = "Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade",

abstract = "The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.",

keywords = "beta blocker, pharmacology, human atrial K+ currents",

author = "G. Marshall and A.C. Rankin and K.A. Kane and A.J. Workman",

note = "AHR: Has abstract also been published in 'Heart' (2006), 92, A101-A101?; World Congress of Cardiology 2006 ; Conference date: 02-09-2006 Through 06-09-2006",

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AU - Rankin, A.C.

AU - Kane, K.A.

AU - Workman, A.J.

N1 - AHR: Has abstract also been published in 'Heart' (2006), 92, A101-A101?

PY - 2006/8

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N2 - The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.

AB - The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.

KW - beta blocker

KW - pharmacology

KW - human atrial K+ currents

U2 - 10.1093/eurheartj/ehl212

DO - 10.1093/eurheartj/ehl212

M3 - Article

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JF - European Heart Journal

IS - Supplement 1

M1 - 389

T2 - World Congress of Cardiology 2006

Y2 - 2 September 2006 through 6 September 2006

ER -

Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade

Abstract

Keywords

UN SDGs

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