Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade

G. Marshall, A.C. Rankin, K.A. Kane, A.J. Workman

Research output: Contribution to journalArticle

Abstract

The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.
Original languageEnglish
Article number389
Pages (from-to)30-30
Number of pages1
JournalEuropean Heart Journal
Volume27
Issue numberSupplement 1
DOIs
Publication statusPublished - Aug 2006
EventWorld Congress of Cardiology 2006 - Barcelona, Spain
Duration: 2 Sep 20066 Sep 2006

    Fingerprint

Keywords

  • beta blocker
  • pharmacology
  • human atrial K+ currents

Cite this

Marshall, G., Rankin, A. C., Kane, K. A., & Workman, A. J. (2006). Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade. European Heart Journal , 27(Supplement 1), 30-30. [389]. https://doi.org/10.1093/eurheartj/ehl212